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Turning up the Heat on Pain: TRPV1 Receptors in Pain and Inflammation / edited by Annika B. Malmberg, Keith R. Bley
Contributor(s): Resource type: Ressourcentyp: Buch (Online)Book (Online)Language: English Series: Progress in Inflammation Research | SpringerLink BücherPublisher: Basel : Birkhäuser Verlag, 2005Description: Online-Ressource (XII, 249 p, digital)ISBN:- 9783764373795
- 616.0472
- 612.88
- 610
- RB127 RD78.3-87.3
- QP451.4
- 2005 M-648
- QV 38
Contents:
Summary: Vanilloids mediate their effects by selective agonism of an ion channel, the vanilloid receptor 1 (TRPV1). TRPV1 is a ligand-gated, non-selective, cation channel preferentially expressed in small-diameter, primary afferent neurons, including nociceptive sensory nerves. In addition to be activated by capsaicin and related vanilloids, TRPV1 responds to heat and extracellular acidification, and will integrate simultaneous exposures to these stimuli. The aim of this book is to summarize recent insights in the role of TRPV1 in pain and inflammation, and to discuss how modulation of this receptor maPPN: PPN: 164732615XPackage identifier: Produktsigel: ZDB-1-SMI | ZDB-2-SME
Hot peppers, pain and analgesics; Structural determinants of TRPV1 functionality; TRPV1 distribution and regulation; Insights into TRPV1 pharmacology provided by non-capsaicin ligands; Endocannabinoids and vanilloid TRPV1 receptors; Vanilloid receptor-mediated hyperalgesia and desensitization; Capsaicin in human experimental pain models of skin, muscle and visceral sensitization; TRPV1 in gut function, abdominal pain and functional bowel disorders; TRPV1 in the airways; TRPV1 agonist-based therapies: mechanism of action and clinical prospects; TRPV1 agonist therapies in bladder diseases
TRPV1 antagonists and chronic pain
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