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Autism : Current Theories and Evidence / by Andrew W. Zimmerman; edited by Daniel Tarsy
Contributor(s): Resource type: Ressourcentyp: Buch (Online)Book (Online)Language: English Series: Current Clinical Neurology | SpringerLink BücherPublisher: Totowa, NJ : Humana Press, 2008Description: Online-Ressource (digital)ISBN:- 9781603274890
- 616.8
- 616.85882
- 616.85/8820072 616.858820072
- RC346-429.2
- RC553.A88
- 2008 M-499
- WM 203.5
Contents:
Summary: Creative thinking and collaborative scientific research have advanced our understanding of autism and we are now beginning to synthesize the data into evidence and theories. Autism: Current Theories and Evidence presents current theories about autism and the evidence that supports them. The goal is to show how the scientific method is revealing the biological bases of this spectrum of disorders, thereby leading the way to their treatment and prevention using evidence-based medicine. This book has 20 chapters divided into 6 sections: Molecular and Clinical Genetics, Neurotransmitters and Cell Signaling, Endocrinology, Growth and Metabolism, Immunology, Maternal-Fetal Effects and Neuroinflammation, Neuroanatomy, Imaging and Neural networks, and Environmental Mechanisms and Models. The subjects cover a wide range of current scientific work in the field of autism, with strong and growing evidence to support them, and demonstrate both the breadth and depth of current autism research. The reader is encouraged to consider how theories and the scientific method, in the hands of these and other dedicated researchers, are leading to greater knowledge and continued progress in autism research.PPN: PPN: 1647777542Package identifier: Produktsigel: ZDB-1-SMI | ZDB-2-SME
Engrailed2 and Cerebellar Development in the Pathogenesis of Autism Spectrum Disorders; Teratogenic Alleles in Autism and Other Neurodevelopmental Disorders; Cholesterol Deficit in Autism: Insights from Smith-Lemli-Opitz Syndrome; Autism in Genetic Intellectual Disability; Serotonin Dysfunction in Autism; Excitotoxicity in Autism; Prenatal ß2-Adrenergic Receptor Signaling and Autism:; A Role for Fetal Testosterone in Human Sex Differences; Interaction between Genetic Vulnerability and Neurosteroids in Purkinje cells as a Possible Neurobiological Mechanism in Autism Spectrum Disorders
Insulin-Like Growth FactorsOxidative Stress and the Metabolic Pathology of Autism; The Immune System in Autism; Maternal Immune Activation, Cytokines and Autism; Maternal Antibodies and the Placental-Fetal IgG Transfer Theory; Can Neuroinflammation Influence the Development of Autism Spectrum Disorders?; The Significance of Minicolumnar Size Variability in Autism; Imaging Evidence for Pathological Brain Development in Autism Spectrum Disorders; Information Processing, Neural Connectivity, and Neuronal Organization; Evidence for Environmental Susceptibility in Autism
An Expanding Spectrum of Autism Models
Part I: Molecular and clinical geneticsENGRAILED2 and cerebellar development in the pathogenesis of autism spectrum disorders / Ian T. Rossman and Emanuel DiCicco-Bloom -- Teratogenic alleles in autism and other neurodevelopmental disorders / William G. Johnson, Madhura Sreenath, Steven Buyske and Edward S. Stenroos -- Cholesterol deficit in autism: insights from Smith-Lemli-Opitz Syndrome / Alka Aneja and Elaine Tierney -- Autism in genetic intellectual disability: insights into idiopathic autism / Walter E. Kaufmann, George T. Capone, Megan Clarke and Dejan B. Budimirovic -- Part II: Neurotransmitters and cell signaling -- Serotonin dysfunction in autism / Mary E. Blue, Michael V. Johnston, Carolyn B. Moloney and Christine F. Hohmann -- Excitotoxicity in autism: the role of glutamate in pathogenesis and treatment / Martin Evers and Eric Hollander -- Prenatal [beta]₂-adrenergic receptor signaling and autism: dysmaturation and retained fetal function / Susan L. Connors -- Part III: Endocrinology, growth, and metabolism -- A role for fetal testosterone in human sex differences: implications for understanding autism / Bonnie Auyeung and Simon Baron-Cohen -- Interaction between genetic vulnerability and neurosteroids in purkinje cells as a possible neurobiological mechanism in autism spectrum disorders / Flavio Keller, Roger Panteri and Filippo Biamonte -- Insulin-like growth factors: neurobiological regulators of brain growth in autism? / Raili Riikonen -- Oxidative stress and the metabolic pathology of autism / S. Jill James -- Part IV: Immunology, maternal-fetal interaction, and neuroinflammation -- The immune system in autism: is there a connection? / Luke Heuer, Paul Ashwood and Judy Van de Water -- Maternal immune activation, cytokines and autism / Paul H. Patterson, Wensi Xu, Stephen E.P. Smith and Benjamin E. Devarman -- Maternal antibodies and the placental-fetal IgG transfer theory / Christina M. Morris, Mikhail Pletnikov, Andrew W. Zimmerman and Harvey S. Singer -- Can neuroinflammation influence the development of autism spectrum disorders? / Carlos A. Pardo-Villamizar -- Part V: Neuroanatomy and neural networks -- The significance of minicolumnar size variability in autism: a perspective from comparative anatomy / Manuel F. Casanova -- Imaging evidence for pathological brain development in autism spectrum disorders / Stephen R. Dager, Seth D. Friedman, Helen Petropoulos and Dennis W.W. Shaw -- Information processing, neural connectivity, and neuronal organization / Nancy J. Minshew, Diane L. Williams and Kathryn McFadden -- Part VI: Environmental mechanisms and models -- Evidence for environmental susceptibility in autism: what we need to know about gene x environment interactions / Isaac N. Pessah and Pamela J. Lein -- An expanding spectrum of autism models: from fixed developmental defects to reversible functional impairments / Martha R. Herbert and Matthew P. Anderson.
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