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Targeted Therapies in Cancer / edited by Manfred Dietel
Resource type: Ressourcentyp: Buch (Online)Book (Online)Language: English Series: Recent Results in Cancer Research ; 176 | SpringerLink BücherPublisher: Berlin, Heidelberg : Springer Berlin Heidelberg, 2007Description: Online-Ressource (XIV, 262 p. 57 illus, digital)ISBN:- 9783540460916
- 616.994
- 616.994061 22
- 610
- RC254-282
- RC271.C5
- W1
- QV 269
Contents:
Summary: From its introduction, oncological chemotherapy has been encumbered by poor selectivity because antiproliferative drugs are often toxic not only to tumor cells but also to important populations of the body's non-neoplastic cells. Modern targeted therapies interact with defined molecules present on cancer cells, adding increased selectivity to their toxic effects. This book presents an integrated critical view on the theories, mechanisms, problems and pitfalls of the targeted therapy approach.Summary: From its introduction, oncological chemotherapy has been encumbered by its poor selectivity because most antiproliferative drugs are toxic not only to tumor cells but also to important populations of the bodys non-neoplastic cells. The resultant problems with unwanted side effects are compounded by difficulties in predicting the desired effectivity of chemotherapy in individual patients. This unsatisfactory situation has driven intensive research and development towards more specific and less toxic anticancer drugs over the last few decades. Several results of these efforts have reached the clinic and an even greater number are now in preclinical testing. Common to all these targeted therapies is their interaction with defined molecules present on cancer cells, which adds various degrees of increased selectivity to their toxic effects. As a consequence, detecting the target molecule on tumors before therapy holds great diagnostic potential for predicting the efficacy of the drug and personalizing therapy. This book aims to present translational scientists and clinicians with an integrated critical view on the theories, mechanisms, problems and pitfalls of the targeted therapy approach.PPN: PPN: 1649026080Package identifier: Produktsigel: ZDB-1-SMI | ZDB-2-SME
Front Matter; Causality in Medicine; The Evolution of the Biomedical Paradigm in Oncology: Implications for Cancer Therapy; Anticancer Drug Discovery and Development; Beyond VEGF: Targeting Tumor Growth and Angiogenesis via Alternative Mechanisms; Aurora Kinases and Their Inhibitors: More Than One Target and One Drug; Signalling Pathways and Adhesion Molecules as Targets for Antiangiogenesis Therapy in Tumors; Developing T-Cell Therapies for Cancer in an Academic Setting; Anticancer Cell Therapy with TRAIL-Armed CD34+ Progenitor Cells
Linking Inflammation Reactions to Cancer: Novel Targets for Therapeutic StrategiesClinical Development of Epidermal Growth Factor Receptor (EGFR) Tyrosine Kinase Inhibitors: What Lessons Have We Learned?; GIST As the Model of Paradigm Shift Towards Targeted Therapy of Solid Tumors: Update and Perspective on Trial Design; Monoclonal Antibodies in the Treatment of Malignant Lymphomas; Molecular Network Analysis using Reverse Phase Protein Microarrays for Patient Tailored Therapy; Back Matter
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