Custom cover image
Recombinant Human Erythropoietin (rhEPO) in Clinical Oncology : Scientific and Clinical Aspects of Anemia in Cancer / edited by Mohammad Resa Nowrousian
Resource type: Ressourcentyp: Buch (Online)Book (Online)Language: English Series: SpringerLink BücherPublisher: Vienna : Springer-Verlag Vienna, 2008Edition: Second, Revised and Enlarged EditionDescription: Online-Ressource (digital)ISBN:- 9783211694596
- 616.994
- 616.99/4061
- RC254-282
- RC641
Contents:
Summary: Anemia is a frequent complication of cancer and its treatment. It produces many symptoms and significantly impairs metabolic and physiologic functions as well as patients' activity, well-being and quality of life. Life expectancy is also affected. This book, now being published in its second edition, comprehensively presents the current knowledge on anemia in cancer and its treatment with rhEPO. Future developments are also discussed. Based on updated and new chapters, including a broader spectrum of topics, outstanding international experts describe the scientific and clinical aspects of anemia in various fields of oncology and give diagnostic and therapeutic recommendations on when and how to use rhEPO. The book, considered as a standard work, will again serve as an essential source of information for radiotherapists, medical oncologists, hematologists, internists, pediatricians, surgeons, specialists in transfusion and laboratory medicine, and pharmacologists.PPN: PPN: 1649748698Package identifier: Produktsigel: ZDB-1-SMI | ZDB-2-SME
Title Page; Copyright Page; Preface; Table of Contents; Contributors; Chapter 1 Physiology of erythropoiesis; Ontogenesis of erythropoiesis; Basic mechanisms in the control of erythropoiesis; Role of EPO, EPO-R, Kit Ligand and c-kit in the control of erythropoiesis; Molecular mechanisms of control of erythropoiesis: role of transcription factors; Anti-apoptotic mechanisms operating in erythroid cells; Role of apoptosis in the control of erythropoiesis; Role of AKT pathway in the apoptotic control of the erythroid lineage
Further signaling pathways involved in the apoptotic regulation of erythroid cellsSummary; References; Chapter 2 Biology of EPO and EPO-receptor; Introduction; Role of EPO in erythropoiesis; Regulation of EPO production; Structure of the EPO receptor; EPO-induced intracellular signalling; Pathways leading to signalling arrest; Acknowledgements; References; Chapter 3 The role of erythropoietin receptor expression on tumor cells; Introduction; Does EPO cause proliferation of tumor cells in vitro?; What does the detection of EPO receptors on tumor cell mean?; Concluding remarks; Acknowledgements
ReferencesChapter 4 Problems associated with erythropoietin receptor determination on tumor cells; Problems with detection of EPO-R; Clinical relevance of erythropoietin doses used in preclinical studies; Effects of erythropoietin on tumor growth and survival: interpretation of preclinical studies; References; Chapter 5 Definition, classification and characterization of anemia in cancer; Definition, diagnosis and grading of anemia; Differential diagnosis of anemia; Anemia in cancer; Conclusion; References; Chapter 6 Pathophysiology of anemia in cancer; Introduction
Hematological characteristicsShortened red blood cell survival; Impaired iron utilization; Suppressed erythroid progenitor cells; Inadequate erythropoietin production; Summary; References; Chapter 7 Prevalence and incidence of anemia and risk factors for anemia in patients with cancer; Definition of anemia; Anemia in cancer; Prevalence of anemia in cancer; Risk factors for prediction of anemia; Acknowledgement; References; Chapter 8 Significance of anemia in cancer chemotherapy; Introduction; Incidence; Pathophysiology; Predictive factors; Prognostic significance; Conclusion; References
Chapter 9 Incidence and impact of anemia in radiation oncologyIntroduction; Frequency of anemia; Prognostic impact of anemia; Explanations for the prognostic impact of anemia; References; Chapter 10 Relationship between hemoglobin levels and tumor oxygenation*; Introduction; Tumor hypoxia and anemia as adverse prognostic factors; Relationship between hemoglobin level and tumor oxygenation: animal studies; Relationship between hemoglobin level and tumor oxygenation: clinical observations; Conclusions; Addendum; Acknowledgement; References; Chapter 11 Tumor hypoxia and therapeutic resistance*
Introduction
No physical items for this record