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When Puberty is Precocious : Scientific and Clinical Aspects / edited by Ora H. Pescovitz, Emily C. Walvoord
Contributor(s): Resource type: Ressourcentyp: Buch (Online)Book (Online)Language: English Series: Contemporary Endocrinology | SpringerLink BücherPublisher: Totowa, NJ : Humana Press, 2007Description: Online-Ressource (XII, 459p. 61 illus, digital)ISBN:- 9781597454995
- 618.92
- 612.6
- 612.6/61 612.661
- RJ1-570
- RJ420.P73 W48 2007
Contents:
Summary: This book focuses on precocious puberty, providing a unique continuum of expertise looking at puberty from anthropologic, epidemiologic, clinical, and molecular perspectives. The volume addresses broad pubertal changes in the general population while at the same time providing in depth information about specific disorders of puberty and the latest management changes. In particular, the book is intended for endocrinologists and internists.Summary: When Puberity is Precocious: Scientific and Clinical Aspects provides a unique continuum of expertise, looking at puberty from anthropologic, epidemiologic, clinical, and molecular perspectives. The volume addresses broad pubertal changes in the general population while at the same time providing in depth information about specific disorders of puberty and the latest management changes. The text is divided into seven parts. The first is an in-depth investigation into neuroendocrine control of puberty, the second looks at secular trends and the onset of puberty, and the third provides an examination into isolated breast development. The fourth section covers adrenal abnormalities and puberty, the next two sections include chapters on gonadotropins effects, and the final section is a looks at environmental effects on puberty. Comprehensive and timely, When Puberity is Precocious: Scientific and Clinical Aspects will become an essential reference for endocrinologists and internists with an interest in precocious puberty.PPN: PPN: 1651476357Package identifier: Produktsigel: ZDB-1-SMI | ZDB-2-SME
Title Page; Copyright Page; Preface; Table of Contents; Contributors; I Neuroendocrine Controlof Puberty; 1 Control Puberty in Rodents:Special Focus on the Female; INTRODUCTION; BASIC ASPECTS OF FEMALE SEXUAL DEVELOPMENTIN RODENTS; PREPUBERTAL CHANGES IN GONADOTROPIN SECRETION; DEVELOPMENT OF STEROID FEEDBACK MECHANISMS; Estradiol Negative Feedback; Estradiol Positive Feedback; CENTRAL CONTROL OF GNRH SECRETION; The Transsynaptic Control; The Glial Control; NEUROENDOCRINE CHANGES AT THE ONSET OF PUBERTY; The Ovary-Independent Activation of GnRH and Gonadotropin Secretion
The Ovary-Dependent Activation of Gonadotropin Secretion: The FirstPreovulatory Surge of GonadotropinsTHE MECHANISM OF THE ONSET OF PUBERTY; The Increase in Excitatory Transsynaptic Output; Glutamatergic Control; Kisspeptin-Dependent Control; The Decrease in Inhibitory Transsynaptic Output; The Coordination of Excitatory and Inhibitory Control Mechanisms; The Change in Glial Output; The Integration of Neuron-to-Neuron and Neuronal-Glial Communicationby Upstream Controlling Genes; The Puberty Clock; PHEROMONES AND RODENT PUBERTY; METABOLIC SIGNALS AND THE ONSET OF PUBERTY; ENDOCRINE DISRUPTORS
POTENTIAL DEFECTS IN NEURONAL-GLIAL CONTROLTHAT MAY LEAD TO CENTRAL PRECOCIOUS PUBERTYDefects Within the GnRH Neuronal Network; Defects in the Transsynaptic Control of GnRH Secretion; Defects Causing Precocious Puberty; Defects Causing Delayed Puberty; Defects in Glial-Neuronal Communication; CONCLUSIONS; ACKNOWLEDGMENTS; REFERENCES; 2 Control of Puberty in Non-HumanPrimates; INTRODUCTION; THE HYPOTHALAMIC NEURAL NETWORK RESPONSIBLEFOR GENERATING PULSATILE GNRH RELEASE; THE ONTOGENY OF PULSATILE GNRH RELEASE
THE NATURE OF THE PREPUBERTAL BRAKE ON PULSATILE GNRHRELEASE DURING JUVENILE DEVELOPMENTNEUROBIOLOGY UNDERLYING THE RESTRAINT OF GNRHFROM BIRTH UNTIL PUBERTY; TIMING OF THE DEVELOPMENTAL SWITCHES RESPONSIBLEFOR THE ON-OFF-ON PATTERN OF PULSATILE GNRH RELEASEFROM BIRTH TO ADULTHOOD; OTHER CONSIDERATIONS; CONCLUSION; ACKNOWLEDGEMENT; REFERENCES; 3 Control of Puberty in Humans; INTRODUCTION; PATTERN OF GONADOTROPIN SECRETION; NEURAL CONTROL; TIMING AND ONSET OF PUBERTY; THE NEGATIVE FEEDBACK MECHANISM(GONADAL STEROID DEPENDENT)
INTERACTION OF NEGATIVE FEEDBACK MECHANISMAND INTRINSIC CNS INHIBITORY MECHANISMPOTENTIAL COMPONENTS OF THE INTRINSIC CNS INHIBITORYMECHANISM; SLEEP-ASSOCIATED LH RELEASE AND ONSET OF PUBERTY; PITUITARY AND GONADAL SENSITIVITY TO TROPIC STIMULI; MATURATION OF POSITIVE FEEDBACK MECHANISM; CONCLUSIONS; REFERENCES; 4 Genetic Regulation of the Variationin Pubertal Timing; INTRODUCTION; CURRENT DATA ON THE GENETIC CONTROLOF PUBERTAL ONSET; APPROACHES TO IDENTIFYING GENETIC FACTORS:HUMAN STUDIES; Resequencing of Candidate Genes; Linkage Analysis; Association Studies; Recent Advances
APPROACHES TO IDENTIFYING GENETIC FACTORS:ANIMAL MODELS
Title Page; Copyright Page; Preface; Table of Contents; Contributors; I Neuroendocrine Controlof Puberty; 1 Control Puberty in Rodents:Special Focus on the Female; INTRODUCTION; BASIC ASPECTS OF FEMALE SEXUAL DEVELOPMENTIN RODENTS; PREPUBERTAL CHANGES IN GONADOTROPIN SECRETION; DEVELOPMENT OF STEROID FEEDBACK MECHANISMS; Estradiol Negative Feedback; Estradiol Positive Feedback; CENTRAL CONTROL OF GNRH SECRETION; The Transsynaptic Control; The Glial Control; NEUROENDOCRINE CHANGES AT THE ONSET OF PUBERTY; The Ovary-Independent Activation of GnRH and Gonadotropin Secretion; The Ovary-Dependent Activation of Gonadotropin Secretion: The FirstPreovulatory Surge of GonadotropinsTHE MECHANISM OF THE ONSET OF PUBERTY; The Increase in Excitatory Transsynaptic Output; Glutamatergic Control; Kisspeptin-Dependent Control; The Decrease in Inhibitory Transsynaptic Output; The Coordination of Excitatory and Inhibitory Control Mechanisms; The Change in Glial Output; The Integration of Neuron-to-Neuron and Neuronal-Glial Communicationby Upstream Controlling Genes; The Puberty Clock; PHEROMONES AND RODENT PUBERTY; METABOLIC SIGNALS AND THE ONSET OF PUBERTY; ENDOCRINE DISRUPTORS; POTENTIAL DEFECTS IN NEURONAL-GLIAL CONTROLTHAT MAY LEAD TO CENTRAL PRECOCIOUS PUBERTYDefects Within the GnRH Neuronal Network; Defects in the Transsynaptic Control of GnRH Secretion; Defects Causing Precocious Puberty; Defects Causing Delayed Puberty; Defects in Glial-Neuronal Communication; CONCLUSIONS; ACKNOWLEDGMENTS; REFERENCES; 2 Control of Puberty in Non-HumanPrimates; INTRODUCTION; THE HYPOTHALAMIC NEURAL NETWORK RESPONSIBLEFOR GENERATING PULSATILE GNRH RELEASE; THE ONTOGENY OF PULSATILE GNRH RELEASE ...
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