Copper-Catalyzed Electrophilic Amination of sp2 and sp3 C−H Bonds / by Stacey L. McDonald

By:

McDonald, Stacey L [aut]

Resource type: Ressourcentyp: Buch (Online)Book (Online)Language: English Series: Springer Theses, Recognizing Outstanding Ph.D. Research | SpringerLink Bücher | Springer eBook Collection Chemistry and Materials SciencePublisher: Cham : Springer, 2016Description: Online-Ressource (XXIII, 144 p. 8 illus, online resource)ISBN:

9783319388786

Subject(s):

Additional physical formats: 9783319388779 | Druckausg.: 978-3-319-38877-9 | Printed edition: 9783319388779 LOC classification:

QD410-412.5

DOI: DOI: 10.1007/978-3-319-38878-6Online resources:

Summary: This thesis reports the latest developments in the direct amination of various C−H bonds using an H−Zn exchange/electrophilic amination strategy. McDonald and co-workers reveal this approach to be a rapid and powerful method for accessing a variety of functionalized amines. The material outlined in this book shows how McDonald achieved C−H zincation using strong, non-nucleophilic zinc bases and subsequent electrophilic amination of the corresponding zinc carbanions with copper as a catalyst and O-benzoylhydroxylamines as the electrophilic nitrogen source. McDonald’s findings are of relevance to medicinal chemistry, drug discovery and materials science. Her thesis is a source of inspiration for scientists entering the field and students beginning their PhD in a related areaSummary: Electrophilic amination for the synthesis of alkyl and aryl amines -- Selective α-amination and α-acylation of esters and amides via dual reactivity of O-acylhydroxylamines toward zinc enolates -- Copper-catalyzed α-amination of phosphonates and phosphine oxides: a direct approach to α-amino phosphonic acids and derivatives -- Copper-Catalyzed Electrophilic Amination of Heteroarenes and Arenes by C−H ZincationPPN: PPN: 1658666054Package identifier: Produktsigel: ZDB-2-CMS | ZDB-2-SEB | ZDB-2-SXC

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