Defects in T Cell Trafficking and Resistance to Cancer Immunotherapy / edited by Emmanuel Donnadieu

Contributor(s):

Donnadieu, Emmanuel [Hrsg.]

Resource type: Ressourcentyp: Buch (Online)Book (Online)Language: English Series: Resistance to Targeted Anti-Cancer Therapeutics ; 9 | SpringerLink BücherPublisher: Cham ; s.l. : Springer International Publishing, 2016Description: Online-Ressource (VIII, 199 p. 27 illus., 19 illus. in color, online resource)ISBN:

9783319422237

Subject(s):

Additional physical formats: 9783319422213 | Druckausg.: 978-3-319-42221-3 LOC classification:

RC261-271

NLM classification:

QZ 266

DOI: DOI: 10.1007/978-3-319-42223-7Online resources:

Summary: Introduction -- Basic rules of T cell migration -- Regulation of anti-tumor T cell migration and function: contribution of real-time imaging -- Vascular normalization, T cell trafficking and anti-tumor immunity -- Disruption of anti-tumor T cell responses by cancer-associated fibroblasts -- Cancer-associated Tertiary Lymphoid Structures, from basic knowledge toward therapeutic target in clinic -- Homing Improvement: Boosting T Cell Trafficking for Cancer Immunotherapy -- Chemokines and T cell trafficking into tumors. Strategies to enhance recruitment of T cells into tumors -- Strategies to enhance migration and persistence of chimeric antigen receptor (CAR)-T cells into tumorsSummary: This volume focuses on recent advances in understanding T cells as key players in antitumor immune responses, and as a result T cell-based immunotherapy is starting to transform the treatment of advanced cancers. However, despite recent successes, many patients with cancer fail to respond to these treatments. Defective migration of T cells into and within tumors is considered as an important resistance mechanism to cancer immunotherapy. The volume includes three sections. The first section covers general knowledge about T cell trafficking during a normal immune response but also during tumor development. The second section provides an in-depth description of the different obstacles that prevent T cells from migrating and contacting tumor cells. The third section explores therapeutic strategies to improve trafficking of T cells into tumors and, thus, to enhance the effectiveness of cancer immunotherapyPPN: PPN: 1658669495Package identifier: Produktsigel: ZDB-2-SBL

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