Validation of Alternative Methods for Toxicity Testing / edited by Chantra Eskes, Maurice Whelan

Contributor(s):

Resource type: Ressourcentyp: Buch (Online)Book (Online)Language: English Series: Advances in Experimental Medicine and Biology ; 856 | Springer eBook Collection | SpringerLink BücherPublisher: Cham ; s.l. : Springer International Publishing, 2016Description: Online-Ressource (XX, 407 p. 44 illus., 40 illus. in color, online resource)ISBN:

9783319338262

Subject(s):

Additional physical formats: 9783319338248 | Erscheint auch als: 978-3-319-33824-8 Druck-AusgabeDDC classification:

615.19

LOC classification:

RS380 RS190-210
RS380
RS190-210

NLM classification:

W 20.55.A5

DOI: DOI: 10.1007/978-3-319-33826-2Online resources:

Summary: Introduction -- Validation in support of internationally harmonised OECD Test Guidelines for assessing the safety of chemicals -- Regulatory acceptance of alternative methods in the development and approval of pharmaceuticals -- Validation of alternative in vitro methods to animal testing: concepts, challenges, processes and tools -- Practical aspects of designing and conducting validation studies involving multi-study trials -- Validation of computational methods -- Implementation of New Test Methods into Practical Testing -- Pathway Based Toxicology and Fit-for-Purpose Assays -- Evidence-based toxicology -- Validation of transcriptomics-based in vitro methods -- Ensuring the quality of stem cell-derived in vitro models for toxicity testing -- Validation of bioreactor and human-on-a-chip devices for chemical safety assessment -- Integrated approaches to testing and assessment -- International harmonization and cooperation in the validation of alternative methods -- Evolving the principles and practice of validation for new alternative approaches to toxicity testingPPN: PPN: 1658841816Package identifier: Produktsigel: ZDB-2-SBL

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