Drug discovery for leishmaniasis / edited by Luis Rivas (Centro de Investigaciones Biológicas, Madrid, Spain) and Carmen Gil (Centro de Investigaciones Biológicas, Madrid, Spain)

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Resource type: Ressourcentyp: Buch (Online)Buch (Online)Sprache: Englisch Reihen: RSC e-book collection | RSC drug discovery series ; no. 60Verlag: Cambridge : Royal Society of Chemistry, [2018]Copyright-Datum: © 2018Beschreibung: 1 Online-Ressource (xix, 402 Seiten) : Illustrationen, DiagrammeISBN:

9781788010177
9781788012584

Schlagwörter:

Andere physische Formen: 9781782628897 LOC-Klassifikation:

RA644.L25

NLM-Klassifikation:

QV 745

DOI: DOI: 10.1039/9781788010177Online-Ressourcen:

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Zusammenfassung: Drug Discovery for Leishmaniasis aims to provide a perspective of the current treatments and their challenges, blended with the emerging strategies and methodologies that will drive new target appraisals and drug developments, as well as addressing the molecular basis of resistance in LeishmaniaZusammenfassung: Leishmaniasis, Impact and Therapeutic Needs; Anti-leishmanial Drug Discovery: Past, Present and Future Perspectives; From Bench to Bedside: Development and Optimization of Clinical Therapies for Visceral Leishmaniasis; Drug Assay Methodology in Leishmaniasis: From the Microplate to Image Analysis; The Pursuit of Novel Anti-leishmanial Agents by High-throughput Screening (HTS) of Chemical Libraries; Omics and Their Impact on the Development of Chemotherapy Against Leishmania; In silico Tools for Target Identification and Drug Molecular Docking in Leishmania; Medicinal Chemistry Strategies to Discover New Leishmanicidal Drugs; Natural Products as a Source of New Drugs Against Leishmania; Organometallic Compounds in Chemotherapy Against Leishmania; New Avenues for Drug Delivery in Leishmania: Using Treatment of Visceral Leishmaniasis with Amphotericin B as an Exemplar; Addressing the Molecular Biology of Leishmania for Drug Development; The Physical Matrix of the Plasma Membrane as a Target: The Charm of Drugs with Low Specificity; Nutrient Transport and Sensing as Pharmacological Targets for Leishmaniasis; Carbon Metabolism as a Drug Target in Leishmania; The Redox Metabolism and Oxidative Stress in Leishmania as a Crossroads for the Lethal Effect of Drugs; DNA Topoisomerases as Promising Targets for Leishmania Chemotherapy; Molecular Basis of Drug Resistance in Leishmania; The Macrophage-Parasite Interface as a Chemotherapeutic Target in LeishmaniasisPPN: PPN: 1659187117Package identifier: Produktsigel: ZDB-1-RSEK

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