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RNA Activation / edited by Long-Cheng Li

Contributor(s): Resource type: Ressourcentyp: Buch (Online)Book (Online)Language: English Series: Advances in Experimental Medicine and Biology ; 983 | SpringerLink Bücher | Springer eBook Collection Biomedical and Life SciencesPublisher: Singapore : Springer, 2017Description: Online-Ressource (XIV, 239 p. 45 illus., 38 illus. in color, online resource)ISBN:
  • 9789811043109
Subject(s): Additional physical formats: 9789811043093 | Erscheint auch als: RNA activation. Buch-Ausgabe. Singapore : Springer, 2017. xiv, 239 Seiten | Printed edition: 9789811043093 LOC classification:
  • QP110.G45
DOI: DOI: 10.1007/978-981-10-4310-9Online resources: Summary: This book offers an essential guide to RNA activation (RNAa), an emerging and fascinating new field. RNAa is a small RNA-guided and Argonaute-dependent gene regulation phenomenon in which promoter-targeted short double-stranded RNAs (dsRNAs) induce target gene expression at the transcriptional level. It occurs primarily in the nucleus and can be mediated by artificially designed short duplex RNAs that target regulatory sequences (e.g., promoters, genes’ 3’ termini and enhancers) and naturally occurring small RNAs (e.g., miRNAs and C. elegans 22G-RNAs). With contributions from internationally respected RNA experts, this book provides comprehensive coverage of different RNAa mechanisms and a timely update on recent advances in RNAa research, with a focus on developing RNAa-based therapeutics. Special chapters are also devoted to the topics of gene activation induced by antisense oligonucleotides and the CRISPR system. As the first book to cover RNAa, it will be of interest to a wide audience, from scientists in academia and the pharmaceutical industry to clinicians who wish to further explore the biology of RNAa and related phenomena, so as to harness their full potential for use in biotechnology and drug developmentSummary: PART I Exogenous RNAa -- PART II Endogenous RNAa -- PART III RNA activation guided by other small RNAs -- PART IV Developing RNAa-based therapeutics --PPN: PPN: 1659350980Package identifier: Produktsigel: ZDB-2-SBL
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