Cell-Based Therapy for Degenerative Retinal Disease / edited by Marco A. Zarbin, Mandeep S. Singh, Ricardo P. Casaroli-Marano

Contributor(s):

Resource type: Ressourcentyp: Buch (Online)Book (Online)Language: English Series: Stem Cell Biology and Regenerative Medicine | Springer eBook Collection | Springer eBooks Biomedical and Life SciencesPublisher: Cham : Humana Press, 2019Description: 1 Online-Ressource (XI, 280 p. 27 illus., 20 illus. in color)ISBN:

9783030052225

Subject(s):

Additional physical formats: 9783030052218 | Erscheint auch als: 978-3-030-05221-8 Druck-AusgabeLOC classification:

QH588.S83

NLM classification:

WW 270

DOI: DOI: 10.1007/978-3-030-05222-5Online resources:

Summary: Advantages of the Eye as a Target Organ for Cell-Based Therapy in the Central Nervous System -- Proof of Principle: Preclinical Data on Retinal Cell Transplantation -- Clinical and Pathological Features of Selected Human Retinal Degenerative Diseases -- Degenerative Retinal Diseases: Cells sources for cell-based therapy -- Manufacturing of Clinical Grade Cellular Products Under Gmp Conditions -- Regulatory Requirements for Cell-Based Therapy for Degenerative Retinal Disease -- Biomaterials and Scaffolds for Cell Replacement Therapy -- Restoration of cone photoreceptor function in retinitis pigmentosa (RP) – retinal cell-based therapy -- Cell Delivery: Surgical Approaches -- Diagnosis and Complementary Examinations -- Cell Therapy for Degenerative Retinal Disease: special focus on cell fusion-mediated regeneration -- Clinical Trials of Retinal Cell Therapy -- Future Directions -- IndexSummary: This book discusses why specific diseases are being targeted for cell-based retinal therapy, what evidence exists that justifies optimism for this approach, and what challenges must be managed in order to bring this technology from the laboratory into routine clinical practice. There are a number of unanswered questions (e.g., surgical approach to cell delivery, management of immune response, optimum cell type to transplant) that very likely are not going to be answered until human trials are undertaken, but there is a certain amount of “de-risking” that can be done with preclinical experimentation. This book is essential reading for scientists, clinicians, and advanced students in stem cell research, cell biology, and ophthalmologyPPN: PPN: 1666750085Package identifier: Produktsigel: ZDB-2-SBL | ZDB-2-SEB | ZDB-2-SXB

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