Efficacy Analysis in Clinical Trials an Update : Efficacy Analysis in an Era of Machine Learning / by Ton J. Cleophas, Aeilko H. Zwinderman

By:

Cleophas, Ton J, 1947- [VerfasserIn]

Contributor(s):

Zwinderman, Aeilko H, 1960- [VerfasserIn]

Resource type: Ressourcentyp: Buch (Online)Book (Online)Language: English Series: Springer eBooks Biomedical and Life Sciences | Springer eBook CollectionPublisher: Cham : Springer, 2019Edition: 1st ed. 2019Description: 1 Online-Ressource (XI, 304 p. 295 illus., 44 illus. in color)ISBN:

9783030199180

Subject(s):

Additional physical formats: 9783030199173 | Erscheint auch als: 978-3-030-19917-3 Druck-AusgabeDDC classification:

610 23

LOC classification:

R-RZ

NLM classification:

WA 950

DOI: DOI: 10.1007/978-3-030-19918-0Online resources:

Summary: Preface -- Traditional and Machine-Learning Methods for Efficacy Analysis -- Optimal-Scaling for Efficacy Analysis -- Ratio-Statistic for Efficacy Analysis -- Ratio-Statistic for Efficacy Analysis -- Complex-Samples for Efficacy Analysis -- Bayesian-Networks for Efficacy Analysis -- Evolutionary-Operations for Efficacy Analysis -- Automatic-Newton-Modeling for Efficacy Analysis -- High-Risk-Bins for Efficacy Analysis -- Balanced-Iterative-Reducing-Hierarchy for Efficacy Analysis -- Cluster-Analysis for Efficacy Analysis -- Multidimensional-Scaling for Efficacy Analysis -- Binary Decision-Trees for Efficacy Analysis -- Continuous Decision-Trees for Efficacy Analysis -- Automatic-Data-Mining for Efficacy Analysis -- Support-Vector-Machines for Efficacy Analysis -- Neural-Networks for Efficacy Analysis -- Ensembled-Accuracies for Efficacy Analysis -- Ensembled-Correlations for Efficacy Analysis -- Gamma-Distributions for Efficacy Analysis -- Validation with Big Data, a Big Issue -- IndexSummary: Machine learning and big data is hot. It is, however, virtually unused in clinical trials. This is so, because randomization is applied to even out multiple variables. Modern medical computer files often involve hundreds of variables like genes and other laboratory values, and computationally intensive methods are required. This is the first publication of clinical trials that have been systematically analyzed with machine learning. In addition, all of the machine learning analyses were tested against traditional analyses. Step by step statistics for self-assessments are included. The authors conclude, that machine learning is often more informative, and provides better sensitivities of testing than traditional analytic methods doPPN: PPN: 1678677744Package identifier: Produktsigel: ZDB-2-SBL | ZDB-2-SEB | ZDB-2-SXB

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