Mucosal Delivery of Drugs and Biologics in Nanoparticles / edited by Pavan Muttil, Nitesh K. Kunda

Mitwirkende(r):

Resource type: Ressourcentyp: Buch (Online)Buch (Online)Sprache: Englisch Reihen: AAPS Advances in the Pharmaceutical Sciences Series ; 41Verlag: Cham : Springer International Publishing, 2020Verlag: Cham : Imprint: Springer, 2020Auflage: 1st ed. 2020Beschreibung: 1 Online-Ressource(VIII, 277 p. 52 illus., 42 illus. in color.)ISBN:

9783030359102

Schlagwörter:

Pharmaceutical technology

615.19 23

DOI: DOI: 10.1007/978-3-030-35910-2Online-Ressourcen:

Zusammenfassung: Section I Background -- Introduction to Nanomedicine -- Characterization of Nanoparticles -- Section II Drugs and Biologics Encapsulated in Nanoparticles -- Routes of Delivery -- Small molecule Delivery -- Peptide and Protein Delivery -- Gene Delivery (siRNA/CRISPR) -- Phage Therapy -- Section III Diseases -- Non-infectious Diseases -- Infectious Diseases -- Cancer -- Section IV Host Interactions with Nanoparticles -- Interaction of Nanoparticles with Epithelial and Immune Cells -- Toxicity of Nanoparticles to the Host -- Nanoparticle Pharmacokinetics and Pharmacodynamics -- Section V MIscellanous -- Nanoparticles as Theranostics -- Regulatory Perspectives -- Manufacturing Scale-up of Nanoparticles.Zusammenfassung: This book focuses on the application of nanotechnology to deliver drugs and biological agents by the mucosal routes of administration i.e. nasal, pulmonary, buccal, and oral routes.It provides an overview of nanotechnology in drug delivery with a description of different types of nanoparticles, methods of preparation and characterization, and functionalization for site-specific drug delivery. Mucosal Delivery of Drugs and Biologics in Nanoparticles emphasize the use of nanoparticles in treating various cancers and infectious diseases. It broadens the use of nanoparticles by including biologics, including vaccines and immunotherapies, apart from drugs. It acknowledges the concerns around the potential toxicity of nanoparticles to the host; few chapters will discuss the biodistribution of these nanoparticles when mucosal routes of administration are employed. Further, the interaction of nanoparticles with the host’s immune cells is discussed. Moreover,it reviews the regulatory aspects of nanotechnology in product development, especially when delivered by the mucosal route of administration. Lastly, discusses the challenges and opportunities to manufacture nanoparticles on an industrial scale. This book will be the first of its kind to focus on the design, development and delivery of nanoparticles when administered by different mucosal routes.PPN: PPN: 1694054160Package identifier: Produktsigel: ZDB-2-SBL | ZDB-2-SEB | ZDB-2-SXB

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