Palladium and Nickel Catalyzed Transformations Forming Functionalized Heterocycles / by Hyung Yoon

By:

Yoon, Hyung [VerfasserIn]

Resource type: Ressourcentyp: Buch (Online)Book (Online)Language: English Series: Springer Theses, Recognizing Outstanding Ph.D. ResearchPublisher: Cham : Springer International Publishing, 2020Publisher: Cham : Imprint: Springer, 2020Edition: 1st ed. 2020Description: 1 Online-Ressource(XXIX, 212 p. 552 illus., 35 illus. in color.)ISBN:

9783030540777

Subject(s):

Additional physical formats: 9783030540760 | 9783030540784 | 9783030540791 | Erscheint auch als: 9783030540760 Druck-Ausgabe | Erscheint auch als: 9783030540784 Druck-Ausgabe | Erscheint auch als: 9783030540791 Druck-AusgabeDOI: DOI: 10.1007/978-3-030-54077-7Online resources:

Summary: Chapter 1. Carbohalogenation Catalyzed by Palladium and Nickel -- Chapter 2. Diastereoselective Pd-Catalyzed Aryl Cyanation and Aryl Borylation -- Chapter 3. Pd-Catalyzed Spirocyclization via C–H Activation and Benzyne/Alkyne Insertion.Summary: This book presents Pd- and Ni-catalyzed transformations generating functionalized heterocycles. Transition metal catalysis is at the forefront of synthetic organic chemistry since it offers new and powerful methods to forge carbon–carbon bonds in high atom- and step-economy. In Chapter 1, the author describes a Pd- and Ni-catalyzed cycloisomerization of aryl iodides to alkyl iodides, known as carboiodination. In the context of the Pd-catalyzed variant, the chapter explores the production of enantioenriched carboxamides through diastereoselective Pd-catalyzed carboiodination. It then discusses Ni-catalyzed reactions to generate oxindoles and an enantioselective variant employing a dual ligand system. Chapter 2 introduces readers to a Pd-catalyzed diastereoselective anion-capture cascade. It also examines diastereoselective Pd-catalyzed aryl cyanation to synthesize alkyl nitriles, a method that generates high yields of borylated chromans as a single diastereomer, and highlights its synthetic utility. Lastly, Chapter 3 presents a Pd-catalyzed domino process harnessing carbopalladation, C–H activation and π-system insertion (benzynes and alkynes) to generate spirocycles. It also describes the mechanistic studies performed on these reactions.PPN: PPN: 1734625376Package identifier: Produktsigel: ZDB-2-CMS | ZDB-2-SEB | ZDB-2-SXC

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