Circadian Pharmacokinetics / edited by Baojian Wu, Danyi Lu, Dong Dong

Contributor(s):

Resource type: Ressourcentyp: Buch (Online)Book (Online)Language: English Series: Springer eBook CollectionPublisher: Singapore : Springer Singapore, 2020Publisher: Singapore : Imprint: Springer, 2020Edition: 1st ed. 2020Description: 1 Online-Ressource(VII, 253 p. 59 illus., 46 illus. in color.)ISBN:

9789811588075

Subject(s):

615 23

DOI: DOI: 10.1007/978-981-15-8807-5Online resources:

Summary: Chapter 1. Introduction to mammalian circadian clock system -- Chapter 2. Introduction to pharmacokinetics -- Chapter 3. Circadian clock and metabolic diseases -- Chapter 4. Circadian clock and CYP metabolism -- Chapter 5. Circadian clock and non-CYP phase I metabolism -- Chapter 6. Circadian clock and phase II metabolism -- Chapter 7. Circadian clock and uptake transporters -- Chapter 8. Circadian clock and efflux transporters -- Chapter 9. Role of pharmacokinetics in chronotherapeutics -- Chapter 10. Role of non-pharmacokinetic factors in chronoefficacy.Summary: This book summarizes the recent advances for the understanding of circadian clock system in the regulation of drug metabolism and pharmacokinetics. Basic knowledge in the field of circadian clock and pharmacokinetics are systemically introduced to make it easier for readers to understand the entire book's contents. The rhythmic expression of DMEs (drug-metabolizing enzymes) and transporters are summarized, and the underlying mechanisms thereof (i.e., regulation by circadian oscillators) are discussed. Typically, evidence for the DME- and transporter-mediated chronopharmacokinetics, chronotoxicity and chronoefficacy are highlighted in this book.PPN: PPN: 1737524562Package identifier: Produktsigel: ZDB-2-SBL | ZDB-2-SEB | ZDB-2-SXB

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