Custom cover image
Custom cover image

Pharmacology of Drug Stereoisomers / by Alexander A. Spasov, Igor N. Iezhitsa, Pavel M. Vassiliev, Alexander A. Ozerov, Renu Agarwal

By: Contributor(s): Resource type: Ressourcentyp: Buch (Online)Book (Online)Language: English Series: Progress in Drug Research ; 76 | Springer eBook CollectionPublisher: Singapore : Springer Nature Singapore, 2022Publisher: Singapore : Imprint: Springer, 2022Edition: 1st ed. 2022Description: 1 Online-Ressource(XI, 207 p. 174 illus., 6 illus. in color.)ISBN:
  • 9789811923203
Subject(s): Additional physical formats: 9789811923197 | 9789811923210 | 9789811923227 | Erscheint auch als: Pharmacology of drug stereoisomers. Druck-Ausgabe Singapore : Springer Nature Singapore, 2022. xi, 207 Seiten | Erscheint auch als: 9789811923210 Druck-Ausgabe | Erscheint auch als: 9789811923227 Druck-AusgabeRVK: RVK: VT 9008DOI: DOI: 10.1007/978-981-19-2320-3Online resources: Summary: Preface -- General principles of chirality -- Quantitative methods of analysing chirality drugs - Chirality and pharmacokinetics -- Drugs regulating the function of peripheral nervous system -- In silico search for chiral drug compounds.Summary: The book is devoted to an important aspect of pharmacology and pharmaceutical chemistry, i.e. the significance of stereoisomerism of drugs for their biological effect from the point of view of their pharmacokinetics, pharmacodynamics and toxicology. The authors review the landmarks in the development of stereochemistry and stereopharmacology. Present-day IUPAC terminology is discussed; general issues of stereoisomerism are considered including separation of racemic mixtures and asymmetric synthesis of isomers, methods of quantifying the isomers of a drug in biological material. The authors put special emphasis on general problems of the influence of stereoisomerism on pharmacological and adverse effects of drugs. A classification of drugs based on stereochemical properties of their isomers is proposed. Possibilities of interaction of stereoisomers in racemic mixtures are discussed. A considerable portion of the book is devoted to pharmacological action of the main groups of drugs whose structure includes asymmetric atoms (that is, drugs with several isomers). Detailed attention is paid to advisability of developing single isomer drugs and to the specifics of their study at the stage of preclinical and clinical trials.PPN: PPN: 1816516090Package identifier: Produktsigel: ZDB-2-SEB | ZDB-2-SBL | ZDB-2-SXB
No physical items for this record

Powered by Koha