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The Chemistry of Elements
Mitwirkende(r): Resource type: Ressourcentyp: Buch (Online)Buch (Online)Sprache: Englisch Reihen: Chemistry Research and Applications SeriesVerlag: New York : Nova Science Publishers, Incorporated, 2023Beschreibung: 1 Online-Ressource (272 p.)ISBN:- 9798891130258
- 546 23/eng/20230901
- QD466
Inhalte:
PPN: PPN: 1882621204Package identifier: Produktsigel: ZDB-4-NLEBK | BSZ-4-NLEBK-KAUB | ZDB-4-EBA
Intro -- Contents -- Preface -- Chapter 1 -- An Evaluation of In Vitro Antiproliferative and Cytotoxic Activity of Novel Ruthenium (II)-Polypyridine Complexes on SK-MEL-28 and Normal L6 Cell Lines -- Abstract -- Introduction -- Ruthenium (II) Complexes as Therapeutic Agents -- Ruthenium(II) Polypyridine ([Ru(NN)3]2+) Complexes -- Biological Importance of [Ru(NN)3]2+ Complexes -- Melanoma -- Skin Cancer -- Ruthenium(II)-Polypyridine Complexes and Their Anticancer Activity -- Synthesis of [Ru(NN)2L2]2+Complexes -- Synthesis of Precursor Complexes [Ru(NN)2Cl2]
Synthesis of [Ru(bpy)2L2](PF6)2 Complexes -- Synthesis of [Ru(phen)2L2](PF6)2 Complexes -- Characterization of [Ru(NN)2L2]2+Complexes -- Absorption Spectral Analysis of [Ru(NN)2L2]2+ Complexes -- Emission and Lifetime Analysis of [Ru(NN)2L2]2+ Complexes -- FT-IR Spectral Analysis of [Ru(NN)2L2]2+ Complexes -- NMR Spectral Analysis of [Ru(NN)2L2]2+ Complexes -- MALDI-TOF Mass Spectral Analysis of [Ru(NN)2L2]2+ Complexes -- Determination of Molar Conductance of [Ru(NN)2L2]2+ Complexes -- Determination of Magnetic Susceptibility of [Ru(NN)2L2]2+ Complexes
Determination of Lipophilicity of [Ru(NN)2L2]2+ Complexes -- Antiproliferative and Cytotoxic Activity of Complexes A-F by Direct Microscopic Method -- Antiproliferative Effect of Complexes A and D on SK-MEL-28 Cell Line -- Cytotoxic Effect of Complexes A and D on Normal L6 Cell Line -- Antiproliferative Effect of Complexes B and E on SK-MEL-28 Cell Line -- Cytotoxic Effect of Complexes B and E on Normal L6 Cell Line -- Antiproliferative Effect of Complexes C and F on SK-MEL-28 Cell Line -- Cytotoxic Effect of Complexes C and F on Normal L6 Cell Line
Antiproliferative and Cytotoxic Activities of Complexes A-F by MTT Assay Method -- Antiproliferative and Cytotoxic Evaluation of Complexes A and D -- Antiproliferative and Cytotoxic Evaluation of Complexes B and E -- Antiproliferative and Cytotoxic Evaluation of Complexes C and F -- Apoptotic Effect of Complexes A-F on SK-MEL-28 and Normal L6 Cell Lines -- Apoptotic Effect of Complexes A and D on SK-MEL-28 and Normal L6 Cell Line -- Apoptotic Effect of Complexes B and E on SK-MEL-28 and Normal L6 Cell Line -- Apoptotic Effect of Complexes C and F on SK-MEL-28 and Normal L6 Cell Line
Conclusion -- Disclaimer -- References -- Biographical Sketch -- Chapter 2 -- Molecular Insight into the Design and Development of Ruthenium Based Anticancer Scaffolds: An Explicative Review -- Abstract -- Introduction -- Chemistry of Ruthenium -- Molecular Mechanism of Different Ruthenium Based Anticancer Scaffold -- Ruthenium Complex Induces Apoptosis -- Ruthenium Complex Induces Cell Cycle Arrest -- Ruthenium Complex Prevents Angiogenesis -- Ruthenium Complex Prevents Metastasis -- Ruthenium Complex Induces Autophagy -- Ruthenium Complex Induces Necroptosis
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