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Synthesis of Medium-Sized Cycloalkenes via Fused-Cyclobutenes / by Tomohiro Ito

By: Resource type: Ressourcentyp: Buch (Online)Book (Online)Language: English Series: Springer Theses, Recognizing Outstanding Ph.D. ResearchPublisher: Singapore : Springer Nature Singapore, 2024Publisher: Singapore : Imprint: Springer, 2024Edition: 1st ed. 2024Description: 1 Online-Ressource(XII, 129 p. 162 illus., 25 illus. in color.)ISBN:
  • 9789819707874
Subject(s): Additional physical formats: 9789819707867 | 9789819707881 | 9789819707898 | Erscheint auch als: 9789819707867 Druck-Ausgabe | Erscheint auch als: 9789819707881 Druck-Ausgabe | Erscheint auch als: 9789819707898 Druck-AusgabeDOI: DOI: 10.1007/978-981-97-0787-4Online resources: Summary: Introduction -- Synthesis of Functionalized Medium-Sized trans-Cycloalkenes by 4π Electrocyclic Ring Opening Alkylation Cascade -- Synthesis of γ-Aryl Medium Sized Cyclic Enones by 4π Electrocyclic Ring Opening Heck Matsuda Arylation Sequence -- Asymmetric Organocatalytic [2+2] Cycloaddition Affording Bicyclo[n.2.0]alkenes -- Conclusion -- Experiments.Summary: This book explains the existence of the intermediate using two approaches: computational chemistry and coordination chemistry. In this book, the author has developed new methods for synthesizing medium-sized cycloalkenes by utilizing the 4π-electrocyclic reaction of fused-cyclobutenes. The fundamental and most important strategy and feature of the work are as follows: first, cyclobutene is used as a readily available raw material with high-strain energy to generate more strained medium-sized cis,trans-cycloalkadiene molecules. Second, by judiciously selecting the reaction conditions, the short-lived intermediate (medium-sized cis,trans-cycloalkadiene) can be converted to medium-sized cis- or trans-cycloalkenes. For the former, the generation of the medium-sized cis,trans-cycloalkadiene intermediate is greatly affected by the substituent on the cyclobutene, and there are few examples of its generation confirmed at room temperature. Regarding the latter, the synthesis of trans-cycloalkenes is noteworthy in terms of establishing a new synthetic methodology and providing one of the few asymmetric synthesis methods, which has not been achieved before. Readers of this book can gain novel insights into strained molecules involved not only in small-sized cycloalkenes but also in medium-sized ones.PPN: PPN: 1885372019Package identifier: Produktsigel: ZDB-2-SEB | ZDB-2-CMS | ZDB-2-SXC
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