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Natural Killer Cells : At the Forefront of Modern Immunology / edited by Jacques Zimmer, Evelyn Ullrich

Contributor(s): Resource type: Ressourcentyp: Buch (Online)Book (Online)Language: English Publisher: Berlin, Heidelberg : Springer Berlin Heidelberg, 2025Publisher: Berlin, Heidelberg : Imprint: Springer, 2025Description: 1 Online-Ressource(Approx. 1000 p.)ISBN:
  • 9783662688168
Subject(s): DDC classification:
  • 571.96 23
  • 616.079 23
DOI: DOI: 10.1007/978-3-662-68816-8Online resources: Summary: Natural Killer cells within the ILC Family -- Natural Killer Cell Development -- Inhibitory and activating NK receptors in humans: an historical overview -- Natural Killer cell differentiation -- Natural killer cell repertoires and functional diversity: calibration through education -- Natural Killer Cells and Memory -- Effect of cytokines on Natural Killer cells -- Natural Killer cells and chemokines -- Natural Killer cell metabolism -- Regulatory Natural Killer Cells -- NK exhaustion (transcriptional changes in exhausted NK cells) -- Natural Killer Cells and Extracellular Vesicles -- Control of Natural Killer Cell Functions by the Nervous System -- NK cells in Inborn Errors of Immunity -- Natural Killer cells in Lymphoid Tissues (lymph nodes) -- Natural Killer cells in the human lung -- Natural Killer cells in the liver -- Natural Killer cells in the Skin -- Natural Killer Cells in the Uterus and the Female Genital Tract -- Natural Killer Cells in the Eye -- Natural Killer Cells in the Nervous System in Health and Disease -- Antifungal Activity of Natural Killer Cells.Summary: The second, completely revised edition summarize the state-of-the-art knowledge about Natural Killer (NK) Cells by focusing on current topics and recent advances. Since their discovery in 1975, NK cells have been continuously and increasingly studied by the scientific community. From the status of an atypical killer, they progressively gained attention and are now considered as highly sophisticated effector cells at the interface between innate and adaptive immunity. During the SARS-Cov-2 virus pandemic it became clear that they can be of therapeutic use showing deleterious effects that have been described before in other circumstances. Split in six parts, this book starts with the basics of NK cells biology and their role in different organs. A special focus is given to their role in cancer, infectious diseases and immunotherapies. The last part reviews unexpected aspects of NK cells in diseases. Given its comprehensive scope, the book serves as a reference for immunologists working in and outside of the NK cell field. Moreover, its logical and consistent structure will make this book appealing not only to confirmed experts but also master and PhD students. .PPN: PPN: 1923381733Package identifier: Produktsigel: ZDB-2-SEB | ZDB-2-143 | ZDB-2-SXRB | ZDB-2-SLR
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