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Silica nanoparticles as drug delivery system for immunomodulator GMDP / E.V. Parfenyuk ... [et al.]
Contributor(s): Resource type: Ressourcentyp: Buch (Online)Book (Online)Language: English Series: Biomedical and nanomedical technologies | Biomedical & nanomedical technologies, concise monograph seriesPublisher: New York, N.Y. : ASME, 2012Description: 1 electronic text (x, 69 p.)ISBN:- 0791860027
- 9780791860021
- 9781606503959
- 9781606504215
- 615.6 23
- RS201.N35
- RS199.5
- QV 786.5.N35
Contents:
Summary: Includes bibliographical references (p. [59]-69)Summary: The development of nanosystems for topical drug delivery to target cells is a promising tool to improve the drug therapeutic index. Transport systems can be designed to control the dispatch of the loaded drug to target areas, increasing its local concentration and bioavailability, while prolonging its retention, half-life and effectiveness. Therefore, such "smart" nanodevices are able to change radically the practice of therapy for a variety of diseases and disorders. The purpose of this book is to present the recent research development of nanoparticulate delivery systems for immune modulating agent, glucosaminyl muramyldipeptides (N-acetylglucosaminyl-Nacetylmuramyl- L-alanyl-D-isoglutamine) or GMDP, which is the main component of bacterial wall with known target of action through NOD2 receptors, with an overlook to their applications for treatment of endometriosis, which often results in infertility. Silica-based nanoparticles have generated a significant amount of interest because of their inherent propertiesSummary: 1. Drug delivery nanosystems as a promising area of modern chemistry and medicine. Silica nanoparticles as potential drug carriers --Summary: 2. Syntheses of mesoporous silica materials -- 2.1 Syntheses of unmodified silica materials -- 2.2 Synthesis of modified silica materials --Summary: 3. Characterization of silica materials as potential carriers for GMDP -- 3.1 Characterization of silica materials via FTIR spectroscopy -- 3.2 Characterization of silica materials via nitrogen adsorption-desorption measurements -- 3.3 Particle size of silica materials -- 3.4 Characterization of silica materials via small angle x-ray scattering (SAXS) -- 3.5 Adsorption properties of silica materials -- 3.6 DSC study of composites of model protein with silica materials -- 3.7 Calorimetric study of adsorption of model protein on silica materials -- 3.8 Preparation of silica nanoparticle suspensions --Summary: 4. Interaction of silica nanoparticles with immune system cells -- 4.1 Intensity of different silica nanoparticles uptake by immune cells -- 4.2 Influence of silica nanoparticles on parameters of functional activity of peritoneal macrophages --Summary: 5. Peritoneal macrophages of women with endometriosis as a possible target for immunomodulatory drugs -- 5.1 Impairment of peritoneal macrophage function at endometriosis -- 5.2 Influence of glucosaminyl muramyldipeptide upon functional activity of peritoneal macrophages of women with endometriosis --Summary: 6. Effectiveness of different types of silica nanoparticles as drug carriers for topical delivery of GMDP into peritoneal macrophages of women with endometriosis -- 6.1 Immobilization of GMDP on silica nanoparticles -- 6.2 Comparative study of the effects of free GMDP and GMD immobilized on silica nanoparticles on the functional state of peritoneal macrophages --Summary: Introduction --Summary: ReferencesSummary: The development of nanosystems for topical drug delivery to target cells is a promising tool to improve the drug therapeutic index. Transport systems can be designed to control the dispatch of the loaded drug to target areas, increasing its local concentration and bioavailability, while prolonging its retention, half-life and effectiveness. Therefore, such "smart" nanodevices are able to change radically the practice of therapy for a variety of diseases and disorders. The purpose of this book is to present the recent research development of nanoparticulate delivery systems for immune modulating agent, glucosaminyl muramyldipeptides (N-acetylglucosaminyl-Nacetylmuramyl- L-alanyl-D-isoglutamine) or GMDP, which is the main component of bacterial wall with known target of action through NOD2 receptors, with an overlook to their applications for treatment of endometriosis, which often results in infertility. Silica-based nanoparticles have generated a significant amount of interest because of their inherent propertiesPPN: PPN: 738307661Package identifier: Produktsigel: ZDB-240-ASM
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