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Peptidomimetics in organic and medicinal chemistry : the art of transforming peptides in drugs / Andrea Trabocchi ; Antonio Guarna

By: Contributor(s): Resource type: Ressourcentyp: BuchBookLanguage: English Publisher: Chichester, West Sussex : Wiley, 2014Description: XIX, 288 S. : Ill., graph. DarstISBN:
  • 9781119950608
Subject(s): Additional physical formats: Erscheint auch als: No title Online-AusgabeDDC classification:
  • 615.1/9 23
  • SCI013050
RVK: RVK: VK 8560 | VX 5200 | VX 5650 | WD 5250LOC classification:
  • RS431.P38
Summary: "Peptidomimetics in Organic and Medicinal Chemistry outlines the concepts and synthetic strategies underlying the building of bioactive compounds of a peptidomimetic nature"--Summary: "A peptidomimetic is a small protein-like chain designed to mimic a peptide with adjusted molecular properties such as enhanced stability or biological activity. It is a very powerful approach for the generation of small-molecule-based drugs as enzyme inhibitors or receptor ligands.Peptidomimetics in Organic and Medicinal Chemistry outlines the concepts and synthetic strategies underlying the building of bioactive compounds of a peptidomimetic nature. Topics covered include the chemistry of unnatural amino acids, peptide- and scaffold-based peptidomimetics, amino acid-side chain isosteres, backbone isosteres, dipeptide isosteres, beta-turn peptidomimetics, proline-mimetics as turn inducers, cyclic scaffolds, amino acid surrogates, and scaffolds for combinatorial chemistry of peptidomimetics. Case studies in the hit-to-lead process, such as the development of integrin ligands and thrombin inhibitors, illustrate the successful application of peptidomimetics in drug discovery"--Call number: Grundsignatur: 2014 A 2850PPN: PPN: 775281646
Holdings
Item type Home library Collection Shelving location Call number Status Barcode
Freihandbestand ausleihbar Bibliothek Campus Süd phar 2 Lesesaal Technik (LST) 2014 A 2850 Available 51992359090
Total holds: 0
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