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LC-NMR and other hyphenated NMR techniques : overview and applications / Maria Victoria Silva Elipe

By: Resource type: Ressourcentyp: Buch (Online)Book (Online)Language: English Publisher: Hoboken, N.J : Wiley, c2012Edition: Online-AusgDescription: Online-Ressource (1 online resource (xviii, 220 p.)) : illISBN:
  • 9781283332262
  • 1283332264
  • 9781118135365
Subject(s): Additional physical formats: 0470548347 | 9781118135365 | 9780470548349 | 1283331624 | Erscheint auch als: LC-NMR and other hyphenated NMR techniques. Druck-Ausgabe Hoboken, New Jersey : Wiley, 2012. XVIII, 220 S.DDC classification:
  • 543/.66 23
  • 543.66
  • SCI078000
RVK: RVK: VG 9500LOC classification:
  • QD96.N8
Online resources: Summary: This practical guide provides a basic overview of the pros and cons of NMR spectroscopy as both a hyphenated and non-hyphenated technique. The book begins with a description of basic NMR concepts for the structural elucidation of organic compounds and then details the historical development of NMR and hyphenated NMR in the structural elucidation world, followed by applications of hyphenated NMR as LC-NMR and LC-MS-NMR in industry and academia. It also contains updated information on the latest advancements and applications of LC-NMR in such areas as degradation products, drug metabolism, food analysis, and drug discovery. An essential resource for scientists in industry and academia who work in the areas of organic chemistry, medicinal chemistry, process chemistry, and analytical chemistry.Summary: LC-NMR and Other Hyphenated NMR Techniques: Overview and Applications -- Contents -- Preface -- Abbreviations, Symbols, and Units -- 1. Basic Concepts of NMR Spectroscopy -- 1.1 Introduction -- 1.2 Basic Knowledge Regarding the Physics of NMR Spectroscopy -- 1.3 Basic Parameters for NMR Interpretation -- 1.3.1 Chemical Shift -- 1.3.2 Spin-Spin Coupling Constants -- 1.3.3 Spin Systems -- 1.3.4 Signal Intensities -- 1.3.5 Bond Correlations -- 1.3.6 Spatial Correlations -- 1.3.7 Other Topics -- 1.4 Conclusions -- References -- 2. Historical Development of NMR and LC-NMR -- 2.1 Introduction -- 2.2 Historical Development of NMR -- 2.3 Historical Development of LC-NMR -- 2.4 Historical Development of Other Analytical Techniques Hyphenated with NMR -- 2.5 Current Trends -- References -- 3. Basic Technical Aspects and Operation of LC-NMR and LC-MS-NMR -- 3.1 Introduction -- 3.2 Technical Considerations Regarding LC-NMR -- 3.2.1 Solvent Compatibility -- 3.2.2 Solvent Suppression -- 3.2.3 NMR Flow Cell -- 3.2.4 LC-NMR Sensitivity -- 3.3 Technical Considerations Regarding LC-MS-NMR -- 3.3.1 Deuterated Solvents -- 3.4 Modes of Operation of LC-NMR -- 3.4.1 On-Flow Mode -- 3.4.2 Stop-Flow Mode -- 3.4.3 Time-Sliced Mode -- 3.4.4 Loop Collection Mode -- 3.5 Modes of Operation of LC-MS-NMR -- 3.5.1 On-Flow Mode -- 3.5.2 Stop-Flow Mode -- 3.6 Other Modes of Operation -- 3.7 Challenging Considerations -- 3.7.1 Air Bubbles -- 3.7.2 Carryover with and Without an Autosampler -- 3.7.3 Sample Solubility and Precipitation -- 3.7.4 Flow Cell and System Cleaning -- 3.7.5 Flow Rate and Magnetic Susceptibility -- 3.7.6 Quantitation -- 3.8 Conclusions -- References -- 4. Applications of LC-NMR -- 4.1 Introduction -- 4.2 Applications of LC-NMR -- 4.2.1 Natural Products -- 4.2.2 Drug Metabolism -- 4.2.3 Drug Discovery -- 4.2.4 Impurity Characterization.PPN: PPN: 807346012Package identifier: Produktsigel: ZDB-26-MYL | ZDB-30-PAD | ZDB-30-PQE
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