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Comparing clinical measurement methods : a practical guide / Bendix Carstensen
Resource type: Ressourcentyp: Buch (Online)Book (Online)Language: English Series: Statistics in practice | Statistics in Practice Ser ; v.108Publisher: Chichester, West Sussex : John Wiley & Sons, 2010Edition: Online-AusgDescription: Online-Ressource (1 online resource (xi, 157 p.)) : ill. (some col.)ISBN:- 9781282653894
- 128265389X
- 9780470683002
- 9780470694237
- Clinical trials
- Clinical Medicine
- Case-Control Studies
- Models, Statistical
- Regression Analysis
- Statistics as Topic
- Clinical trials ; Evaluation
- Clinical trials ; Statistical methods
- Electronic books
- Clinical trials Evaluation
- Clinical Medicine
- Case-Control Studies
- Models, Statistical
- Regression Analysis
- Statistics as Topic methods
- Electronic books
- 610.724
- 610.72/4
- 614.40727
- R853.C55
- R853.C55C37 2010
- WA 950
Contents:
Summary: This book provides a practical guide to analysis of simple and complex method comparison data, using Stata, SAS and R. It takes the classical Limits of Agreement as a starting point, and presents it in a proper statistical framework. The model serves as a reference for reporting sources of variation and for providing conversion equations and plots between methods for practical use, including prediction uncertainty. Presents a modeling framework for analysis of data and reporting of results from comparing measurements from different clinical centers and/or different methods. Provides the practical tools for analyzing method comparison studies along with guidance on what to report and how to plan comparison studies and advice on appropriate software. Illustrated throughout with computer examples in R. Supported by a supplementary website hosting an R-package that performs the major part of the analyses needed in the area. Examples in SAS and Stata for the most common situations are also provided. Written by an acknowledged expert on the subject, with a long standing experience as a biostatistician in a clinical environment and a track record of delivering training on the subject. Biostatisticians, clinicians, medical researchers and practitioners involved in research and analysis of measurement methods and laboratory investigations will benefit from this book. Students of statistics, biostatistics, and the chemical sciences will also find this book useful.Summary: Intro -- Comparing Clinical Measurement Methods -- Contents -- Acknowledgments -- 1 Introduction -- 2 Method comparisons -- 2.1 One measurement by each method -- 2.1.1 Prediction of one method from another -- 2.1.2 Why not use the correlation? -- 2.1.3 A new method and a reference method -- 2.2 Replicate measurements by each method -- 2.2.1 Exchangeable replicates: fat data -- 2.2.2 Linked replicates: oximetry data -- 2.2.3 Why not use the averages of the replicates? -- 2.3 More than two methods -- 2.4 Terminology and notation -- 2.5 What it is all about -- 3 Howto. . . -- 3.1 . . . use this chapter -- 3.2 Two methods -- 3.2.1 Single measurements -- 3.2.2 Comparing with a gold standard -- 3.2.3 Replicate measurements -- 3.3 More than two methods -- 3.3.1 Single measurements -- 3.3.2 Replicate measurements -- 4 Two methods with a single measurement on each -- 4.1 Model for limits of agreement -- 4.1.1 Prediction between methods -- 4.1.2 The correlation of the difference and the average -- 4.2 Non-constant difference between methods -- 4.3 A worked example -- 4.4 What really goes on -- 4.4.1 Scaling -- 4.4.2 Independence -- 4.4.3 Actual behavior -- 4.5 Other regression methods for non-constant bias -- 4.5.1 Why ordinary regression fails -- 4.5.2 Deming regression -- 4.6 Comparison with a gold standard -- 4.7 Non-constant variance -- 4.7.1 Regression approach -- 4.7.2 A worked example -- 4.8 Transformations -- 4.8.1 Log transformation -- 4.9 Summary -- 5 Replicate measurements -- 5.1 Pairing of replicate measurements -- 5.1.1 Exchangeable replicates -- 5.1.2 Linked replicates -- 5.2 Plotting replicate measurements -- 5.3 Models for replicate measurements -- 5.3.1 Exchangeable replicates -- 5.3.2 Linked replicates -- 5.4 Interpretation of the random effects -- 5.5 Estimation -- 5.6 Getting it wrong and getting it almost right.PPN: PPN: 808918877Package identifier: Produktsigel: ZDB-26-MYL | ZDB-30-PAD | ZDB-30-PQE
Comparing Clinical Measurement Methods; Contents; Acknowledgments; 1 Introduction; 2 Method comparisons; 3 Howto. . .; 4 Two methods with a single measurement on each; 5 Replicate measurements; 6 Several methods of measurement; 7 A general model for method comparisons; 8 Transformation of measurements; 9 Repeatability, reproducibility and coefficient of variation; 10 Measures of association and agreement; 11 Design of method comparison studies; 12 Examples using standard software; 13 The MethComp package for R; References; Index;
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