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Mass spectrometry handbook / edited by Mike S. Lee
Contributor(s): Resource type: Ressourcentyp: Buch (Online)Book (Online)Language: English Series: Wiley series on pharmaceutical science and biotechnology: practices, applications and methods | Wiley Series on Pharmaceutical Science and Biotechnology: Practices, Applic Ser ; v.7 | Wiley Series on Pharmaceutical Science and Biotechnology: Practices, Applications and Methods Ser ; v.7Publisher: Hoboken, N.J : J. Wiley & Sons, c2012Edition: Online-AusgDescription: Online-Ressource (1 online resource (xxi, 1340 p.)) : illISBN:- 9781280592591
- 1280592591
- 9781118180709
- 543/.65 23
- 543.65
- QD96.M3
Contents:
Summary: Due to its enormous sensitivity and ease of use, mass spectrometry has grown into the analytical tool of choice in most industries and areas of research. This unique reference provides an extensive library of methods used in mass spectrometry, covering applications of mass spectrometry in fields as diverse as drug discovery, environmental science, forensic science, clinical analysis, polymers, oil composition, doping, cellular research, semiconductor, ceramics, metals and alloys, and homeland security. The book provides the reader with a protocol for the technique described (including sampling methods) and explains why to use a particular method and not others. Essential for MS specialists working in industrial, environmental, and clinical fields.Summary: Intro -- MASS SPECTROMETRY HANDBOOK -- CONTENTS -- FOREWORD -- PREFACE -- CONTRIBUTORS -- SECTION I: BIOTECHNOLOGY/PROTEINS -- 1: TARGETED PROTEOMICS USING IMMUNOAFFINITY PURIFICATION -- 2: MASS SPECTROMETRY-BASED METHODS TO INVESTIGATE POSTTRANSLATIONAL PROTEIN MODIFICATIONS BY LIPID PEROXIDATION PRODUCTS -- 3: IMAGING MASS SPECTROMETRY (IMS) FOR BIOLOGICAL APPLICATION -- 4: METHODOLOGIES FOR IDENTIFYING MICROORGANISMS AND VIRUSES BY MASS CATALOGING OF RNAs -- SECTION II: PHARMACEUTICAL -- 5: PRECLINICAL PHARMACOKINETICS: INDUSTRIAL PERSPECTIVE -- 6: LC-MS IN DRUG METABOLISM AND PHARMACOKINETICS: A PHARMACEUTICAL INDUSTRY PERSPECTIVE -- 7: QUANTITATIVE MASS SPECTROMETRY IN SUPPORT OF PHARMACOKINETIC STUDIES -- 8: DETERMINATION OF PHARMACOKINETIC PARAMETERS BY HPLC-MS/MS AND UPLC-MS/MS -- 9: METHODS FOR SCREENING ENANTIOSELECTIVE INTERACTIONS IN THE SOLUTION PHASE USING ESI-MS -- 10: HYDROGEN/DEUTERIUM EXCHANGE MASS SPECTROMETRY (HDX MS) IN THE STUDIES OF ARCHITECTURE, DYNAMICS, AND INTERACTIONS OF BIOPHARMACEUTICAL PRODUCTS -- 11: TOF-SIMS APPLICATIONS TO BIOIMAGING AND BIOMOLECULE EVALUATION METHODS -- 12: ACCELERATOR MASS SPECTROMETRY IN PHARMACEUTICAL DEVELOPMENT -- SECTION III: CLINICAL ANALYSIS -- 13: MASS SPECTROMETRY IN CLINICAL ANALYSIS: SCREENING FOR INBORN ERRORS IN METABOLISM -- 14: MASS SPECTROMETRY FOR STEROID ANALYSIS -- SECTION IV: FORENSICS -- 15: FORENSIC APPLICATIONS OF ISOTOPE RATIO MASS SPECTROMETRY -- 16: ANALYSIS OF TRIACETONE TRIPEROXIDE EXPLOSIVE BY MASS SPECTROMETRY -- SECTION V: SPACE EXPLORATION -- 17: MASS SPECTROMETRY IN SOLAR SYSTEM EXPLORATION -- 18: APPLICATION OF GC × GC-TOFMS TO THE CHARACTERIZATION OF EXTRATERRESTRIAL ORGANIC MATTER -- SECTION VI: HOMELAND SECURITY -- 19: METHODS OF MASS SPECTROMETRY IN HOMELAND SECURITY APPLICATIONS -- 20: HOMELAND SECURITY -- 21: MASS SPECTROMETRY IN HOMELAND SECURITY.PPN: PPN: 809669323Package identifier: Produktsigel: ZDB-26-MYL | ZDB-30-PAD | ZDB-30-PQE
""WILEY SERIES ON PHARMACEUTICAL SCIENCE AND BIOTECHNOLOGY: PRACTICES, APPLICATIONS AND METHODS""; ""Title page""; ""Copyright page""; ""FOREWORD""; ""PREFACE""; ""CONTRIBUTORS""; ""SECTION I: BIOTECHNOLOGY/PROTEINS""; ""1 TARGETED PROTEOMICS USING IMMUNOAFFINITY PURIFICATION""; ""1.1Â INTRODUCTION""; ""1.2Â EXPERIMENTAL PROTOCOLS""; ""1.3Â APPLICATIONS OF THE PROTOCOLS""; ""1.4Â CONCLUSION""; ""ACKNOWLEDGMENTS""; ""2 MASS SPECTROMETRY-BASED METHODS TO INVESTIGATE POSTTRANSLATIONAL PROTEIN MODIFICATIONS BY LIPID PEROXIDATION PRODUCTS""; ""2.1Â PROCEDURE CONTROL""
""2.2 IDENTIFICATION OF HNE-MODIFIED PEPTIDES IN BIOLOGICAL SAMPLES BY SOLID-PHASE ENRICHMENT AND NANO-LCâ€"ESI-MS/MS""""2.3 REAGENTS AND STANDARDS""; ""2.4 COMMENTARY""; ""ACKNOWLEDGMENTS""; ""3 IMAGING MASS SPECTROMETRY (IMS) FOR BIOLOGICAL APPLICATION""; ""3.1 INTRODUCTION""; ""3.2 APPLICATIONS OF MALDI-IMS""; ""3.3 EXPERIMENTAL PROCEDURES""; ""3.4 STATISTICAL PROCEDURES FOR IMS DATA ANALYSIS""; ""4 METHODOLOGIES FOR IDENTIFYING MICROORGANISMS AND VIRUSES BY MASS CATALOGING OF RNAs""; ""4.1 INTRODUCTION: THE IMPORTANCE OF MICROBIAL GENOTYPING""
""4.2Â INFORMATICS: ENABLING ASPECTS OF 16S RRNA AND DATABASE CONSTRUCTION""""4.3Â EXPERIMENTAL METHODS: PCR, TRANSCRIPTION, AND ENZYMATIC FRAGMENTATION""; ""4.4Â DATABASE COMPARISON AND RESULTS: TYPICAL RESULTS OF BACTERIAL AND VIRAL GENOTYPING""; ""4.5Â DISCUSSION""; ""ACKNOWLEDGMENTS""; ""SECTION II: PHARMACEUTICAL""; ""5 PRECLINICAL PHARMACOKINETICS: INDUSTRIAL PERSPECTIVE""; ""5.1Â INTRODUCTION""; ""5.2Â A PHARMACOKINETICS PRIMER""; ""5.3Â PARAMETERS THAT DEFINE PHARMACOKINETIC PROFILE""; ""5.4Â MODELING TO PREDICT SINGLE- AND MULTIPLE-DOSE PHARMACOKINETIC PROFILES""
""5.5Â ROLE OF LC/MS/MS IN PHARMACOKINETIC ASSESSMENT IN DRUG DISCOVERY""""6 LC-MS IN DRUG METABOLISM AND PHARMACOKINETICS: A PHARMACEUTICAL INDUSTRY PERSPECTIVE""; ""6.1Â INTRODUCTION""; ""6.2Â INSTRUMENTATION UTILIZED FOR DMPK STUDIES""; ""6.3Â LC-MS FOR IN VITRO ADME SCREENING""; ""6.4Â LC-MS FOR IN VIVO BIOANALYSIS IN SUPPORT OF DMPK""; ""6.5Â LC-MS IN DRUG METABOLITE PROFILING AND IDENTIFICATION""; ""6.6Â SUMMARY AND PERSPECTIVE""; ""ACKNOWLEDGMENTS""; ""7 QUANTITATIVE MASS SPECTROMETRY IN SUPPORT OF PHARMACOKINETIC STUDIES""; ""7.1Â INTRODUCTION""; ""7.2Â METHODOLOGY""
""7.3Â CURRENT PROTOCOL""""7.4Â DEFINITIONS""; ""8 DETERMINATION OF PHARMACOKINETIC PARAMETERS BY HPLC-MS/MS AND UPLC-MS/MS""; ""8.1Â INTRODUCTION""; ""8.2Â LC-MS/MS ASSAYS FOR PK DETERMINATION IN DRUG DISCOVERY""; ""8.3Â PK EVALUATION OF LEAD CANDIDATE AND METABOLITES IN PRECLINICAL DEVELOPMENT""; ""8.4Â PK ASSAYS FOR DRUG CANDIDATE DURING CLINICAL DEVELOPMENT""; ""8.5Â CONCLUSION""; ""9 METHODS FOR SCREENING ENANTIOSELECTIVE INTERACTIONS IN THE SOLUTION PHASE USING ESI-MS""; ""9.1Â INTRODUCTION""; ""9.2Â ENANTIOSELECTIVE DISCRIMINATION BY MS""
""9.3Â MEASURING ENANTIOSELECTIVE DISCRIMINATION IN SOLUTION WITH ESI-MS""
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