Custom cover image
Custom cover image

Vaccinology : principles and practice / edited by W. John W. Morrow ... [et al.]

Contributor(s): Resource type: Ressourcentyp: Buch (Online)Book (Online)Language: English Publisher: Chichester : Wiley-Blackwell, 2012Edition: Online-AusgDescription: Online-Ressource (1 online resource (xii, 540 p.)) : illISBN:
  • 9781280698170
  • 1280698179
  • 9781118345337
Subject(s): Additional physical formats: 9781405185745 | 1280697342 | Erscheint auch als: Vaccinology. Druck-Ausgabe. Oxford : Wiley-Blackwell, 2012. XII, 540 S.DDC classification:
  • 615.3/72 23
  • 615.372
RVK: RVK: XD 3300LOC classification:
  • QR189
NLM classification:
  • QW 805
Online resources: Summary: Covering all aspects of vaccine research and development in one volume, this authoritative resource takes a comprehensive and systematic approach to the science of vaccinology focusing not only on basic science, but also on the many stages required to commercialize and navigate the regulatory requirements for human application, both in the United States and Europe. Reviews in detail the process of designing a vaccine, from the initial stages of antigen discovery to human application Includes evaluation of vaccine efficacy and safety Details clinical trial design, including regulatory requirements Discusses the emerging field of active cellular immunotherapy Vaccinology: Principles and Practice provides an invaluable resource for clinicians, scientific and medical researchers, lecturers and postdoctoral fellows working in the field of vaccines.Summary: Intro -- Vaccinology: Principles and Practice -- Contents -- List of Contributors -- Preface -- PART 1 Introduction -- CHAPTER 1 Concept and Scope of Modern Vaccines -- Introduction -- Triumphs and limitations of current vaccination -- Modern approaches that impact vaccine design -- Genomics -- Improved delivery systems and adjuvants -- Therapeutic vaccination -- A return to attenuated organisms? -- Improve existing vaccines and vaccine uptake -- Hurdles and challenges for the future -- Non-infectious diseases as targets for modern vaccines -- Transition from research to trial -- References -- PART 2 Principles of Vaccine Design -- CHAPTER 2 Strategies to Stimulate Innate Immunity for Designing Effective Vaccine Adjuvants -- Principles of vaccine design: stimulation of innate immunity -- Innate immune stimulators -- Toll-like receptors -- Non-Toll-like receptors -- Practical applications for adjuvants -- Action -- Safety -- Summary -- Acknowledgements -- References -- CHAPTER 3 Antigen Processing and Presentation by MHC Class I, II, and Nonclassical Molecules -- MHC class I and II structure -- Structural composition -- The peptide-binding grooves -- Nonclassical MHC class I molecules -- MHC molecule assembly -- Pre-peptide loading complex stage of MHC class I folding -- The peptide-loading complex and export to the cell surface -- MHC class II molecules and the invariant chain -- The MHC class II peptide loading complex -- Peptide generation -- Peptide generation in the MHC class I pathway -- Peptide generation in the MHC class II pathway -- Cross- and criss-cross presentation -- Summary -- Acknowledgments -- References -- CHAPTER 4 Understanding the Mucosal Immune System for Better Mucosal Vaccine Design -- Introduction -- Anatomy of the mucosal immune system -- Players of the mucosal immune system -- Mucosal epithelium.PPN: PPN: 809700808Package identifier: Produktsigel: ZDB-26-MYL | ZDB-30-PAD | ZDB-30-PQE
No physical items for this record
KIT – The University in the Helmholtz Association                         Home | Impressum | Datenschutz | Barrierefreiheit | KIT