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Muscle : fundamental biology and mechanisms of disease / ed. by Joseph A. Hill ...
Contributor(s): Resource type: Ressourcentyp: Buch (Online)Book (Online)Language: English Publisher: London ; Waltham, MA : Elsevier/Academic Press, 2012Edition: 1st ed (Online-Ausg.)Description: Online-Ressource (1 online resource (2 v.)) : ill. (chiefly col.)ISBN:- 9781280779152
- 1280779152
- 9780123815118
- 9780123815101
- 616.74
- 616.7/4 23
- 573.75
- 612.74
- RC925.5
- RC927.5.N65 .H384 2012
- WE 550
Contents:
Summary: A valuable study of the science behind the medicine, Muscle: Fundamental Biology and Mechanisms of Disease brings together key leaders in muscle biology. These experts provide state-of-the-art insights into the three forms of muscle--cardiac, skeletal, and smooth--from molecular anatomy, basic physiology, disease mechanisms, and targets of therapy. Commonalities and contrasts among these three tissue types are highlighted. This book focuses primarily on the biology of the myocyte. Individuals active in muscle investigation--as well as those new to the field--will find this work useful, as will students of muscle biology. In the case of hte former, many wish to grasp issues at the margins of their own expertise (e.g. clinical matters at one end; molecular matters at the other), adn this book is designed to assist them. Students, postdoctoral fellows, course directors and other faculty will find this book of interest. Beyond this, many clinicians in training (e.g. cardiology fellows) will benefit. The only resource to focus on science before the clinical work and therapeutics Tiered approach to subject: discussion first of normal muscle function through pathological/disease state changes, and ending each section with therapeutic interventions Coverage of topics ranging from basic physiology to newly discovered molecular mechanisms of muscle diseases for all three muscle types: cardiac, skeletal, and smooth.Summary: Intro -- MUSCLE: Fundamental Biology and Mechanisms of Disease -- Copyright Page -- Contents -- List of Contributors -- Acknowledgments -- Volume 1 -- Part I Introduction -- Chapter 1 An Introduction to Muscle -- Chapter 2 A History of Muscle -- Part II Cardiac Muscle -- Section A Basic Physiology -- Chapter 3 Cardiac Myocyte Specification and Differentiation -- Chapter 4 Transcriptional Control of Cardiogenesis -- Chapter 5 Cardiomyocyte Ultrastructure -- Chapter 6 Overview of Cardiac Muscle Physiology -- Chapter 7 Ionic Fluxes and Genesis of the Cardiac Action Potential -- Chapter 8 G-Protein-Coupled Receptors in the Heart -- Chapter 9 Receptor Tyrosine Kinases in Cardiac Muscle -- Chapter 10 Communication in the Heart: Cardiokines as Mediators of a Molecular Social Network -- Chapter 11 Calcium Fluxes and Homeostasis -- Chapter 12 Excitation-Contraction Coupling in the Heart -- Chapter 13 Role of Sarcomeres in Cellular Tension, Shortening, and Signaling in Cardiac Muscle -- Chapter 14 Cardiovascular Mechanotransduction -- Chapter 15 Cardiomyocyte Metabolism: All Is in Flux -- Chapter 16 Transcriptional Control of Striated Muscle Mitochondrial Biogenesis and Function -- Chapter 17 Mitochondrial Morphology and Function -- Chapter 18 Genetics and Genomics in Cardiovascular Gene Discovery -- Chapter 19 Cardiovascular Proteomics: Assessment of Protein Post-Translational Modifications -- Section B Adaptations and Response -- Chapter 20 Adaption and Responses: Myocardial Innervations and Neural Control -- Chapter 21 Regulation of Cardiac Systolic Function and Contractility -- Chapter 22 Intracellular Signaling Pathways in Cardiac Remodeling -- Chapter 23 Oxidative Stress and Cardiac Muscle -- Chapter 24 Physiologic and Molecular Responses of the Heart to Chronic Exercise -- Chapter 25 Epigenetics in Cardiovascular Biology.PPN: PPN: 809711443Package identifier: Produktsigel: ZDB-26-MYL | ZDB-30-PAD | ZDB-30-PQE
Volume 1; Volume 2; III. Skeletal Muscle; Section A: Basic Physiology; 53. Skeletal Muscle: Architecture of Membrane Systems; The Membrane Systems Involved in Calcium Cycling; Calcium Cycling and the Control of Muscle Contraction: the EC Coupling Question; T-tubules Are Surface Invaginations; the SR Is an Internal Membrane System; Junctional SR and Junctional T-tubule Domains and Their Interaction at CRUs; Molecular Composition of CRUs; Feet/ SR Calcium Release Channels/RyRs; L Type Calcium Channels and Voltage Sensing; Co-localization of jSR Proteins: the SR as a Calcium Storage Compartment
Muscle Relaxation: Free SR and the Calcium PumpMitochondria; Golgi and Associated Organelles; Pathology of Myofibrils and Membrane Systems; Z Line Defects in Pathology; Defects of the Membrane Systems; Acknowledgments; References; 56. Control of Resting Ca2+ Concentration in Skeletal Muscle; Introduction; Mechanisms for Ca2+ Removal from the Myoplasm of Muscle Cells; Sarcolemmal Outward Ca2+ Transport Mechanisms; Sodium Calcium Exchanger (NCX); Plasma Membrane Ca2+-ATPase (PMCA); SR Ca2+ Reuptake: the SERCA Pump; Mechanisms for Ca2+ Entry into the Myoplasm in Skeletal Muscle
Sarcolemmal Ca2+ Entry MechanismsExcitation-Coupled Ca2+ Entry (ECCE); Store-Operated Ca2+ Entry (SOCE); Transient Receptor Potential Channels (TRPs); Resting Ca2+ Entry and Resting [Ca2+]i; SR Ca2+ Leak; Methods for Measurements Resting [Ca2+]I in Muscle Cells; Optical Indicators; Photoproteins; Metalochromic Dyes; Tetracarboxylate Fluorescent Ca2+ Chelator Dyes; Ca2+-Selective Microelectrodes; Summary; Acknowledgments; References
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