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Modern tools for the synthesis of complex bioactive molecules / edited by Janine Cossy, Stellios Arseniyadis

Contributor(s): Resource type: Ressourcentyp: Buch (Online)Book (Online)Language: English Publisher: Hoboken, N.J : John Wiley & Sons, c2012Edition: Online-AusgDescription: Online-Ressource (1 online resource (xiii, 581 p.)) : ill. (some col.)ISBN:
  • 9781283598910
  • 1283598914
  • 9781118342855
Subject(s): Additional physical formats: 9780470616185. | 1283598809 | Erscheint auch als: Modern tools for the synthesis of complex bioactive molecules. Druck-Ausgabe. Hoboken, N.J. : Wiley, 2012. XIII, 581 S.DDC classification:
  • 547.139
  • SCI007000
RVK: RVK: VK 5500LOC classification:
  • QD415
Online resources: Summary: MODERN TOOLS FOR THE SYNTHESIS OF COMPLEX BIOACTIVE MOLECULES -- CONTENTS -- FOREWORD -- PREFACE -- CONTRIBUTORS -- CHAPTER 1: C-H FUNCTIONALIZATION: A NEW STRATEGY FOR THE SYNTHESIS OF BIOLOGICALLY ACTIVE NATURAL PRODUCTS -- 1.1. INTRODUCTION -- 1.2. PALLADIUM(0)-CATALYZED INTRAMOLECULAR DIRECT ARYLATION -- 1.3. PALLADIUM(0)-CATALYZED INTRAMOLECULAR ALKENYLATION OF sp2 C-H BONDS -- 1.4. PALLADIUM(0)-CATALYZED INTRAMOLECULAR ARYLATION OF sp3 C-H BONDS -- 1.5. PALLADIUM(II)-MEDIATED INTRAMOLECULAR OXIDATIVE ALKENYLATION OF sp2 C-H BONDS -- 1.6. DIRECTING GROUP-ASSISTED PALLADIUM(II)- ENABLED CARBON-CARBON BOND FORMATION AT sp3 C-H BONDS -- 1.7. PLATINUM(II)-MEDIATED ALKANE DEHYDROGENATION -- 1.8. PALLADIUM(II)-ENABLED CARBON-OXYGEN BOND FORMATION AT sp3 C-H BONDS -- 1.9. IRIDIUM-CATALYZED BORYLATION OF sp2 C-H BONDS -- 1.10. RHODIUM(I)-CATALYZED INTRAMOLECULAR DIRECTED ALKYLATION OF sp2 C-H BONDS -- 1.11. RHODIUM(III)-CATALYZED SYNTHESIS OF NITROGEN-CONTAINING HETEROCYCLES -- 1.12. CONCLUSION -- REFERENCES -- CHAPTER 2: THE NEGISHI CROSS-COUPLING IN THE SYNTHESIS OF NATURAL PRODUCTS AND BIOACTIVE MOLECULES -- 2.1. INTRODUCTION -- 2.2. SYNTHESIS OF NATURAL PRODUCTS -- 2.2.1. Synthesis of Polyenes -- 2.2.2. Synthesis of Amino Acids and Macrocyclic Peptides -- 2.2.3. Synthesis of Macrocycles -- 2.2.4. Synthesis of Small Heterocycles -- 2.3. LARGE-SCALE SYNTHESIS OF BIOLOGICALLY ACTIVE MOLECULES -- 2.3.1. Nonsteroidal Ligand A-224817.0 1A -- 2.3.2. Phosphodiesterase Inhibitor PDE472 -- 2.3.3. Reverse Transcriptase Inhibitor MIV-150 -- 2.3.4. B-Raf Kinase Inhibitors -- 2.3.5. mGluR1 Antagonist -- 2.4. CONCLUSION -- REFERENCES -- CHAPTER 3: METAL-CATALYZED C-HETEROATOM CROSS-COUPLING REACTIONS -- 3.1. GENERAL INTRODUCTION -- 3.2. BUCHWALD-HARTWIG-TYPE REACTIONS -- 3.2.1. Introduction -- 3.2.2. Mechanism -- 3.2.3. Scope and Limitations.PPN: PPN: 809885549Package identifier: Produktsigel: ZDB-26-MYL | ZDB-30-PAD | ZDB-30-PQE
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