Viruses : agents of evolutionary invention / Michael G. Cordingley

Von:

Cordingley, Michael G, 1958- [VerfasserIn]

Resource type: Ressourcentyp: Buch (Online)Buch (Online)Sprache: Englisch Verlag: Cambridge, Massachusetts : Harvard University Press, 2017Beschreibung: 1 Online-Ressource (vii, 373 pages)ISBN:

0674978633
9780674978638

Schlagwörter:

Andere physische Formen: 0674972082 | 9780674972087 | 0674978633. | 9780674978638. LOC-Klassifikation:

QR370

NLM-Klassifikation:

QW 160

Online-Ressourcen:

Zugang im Netz des KIT

Zusammenfassung: 1. Obligate parasites of cells: Discovery -- The virosphere and its metagenome -- Complexity and "dark matter" -- Selfish information and the essence of being viral -- The emergence of egotistical replicators -- The viral empire -- 2. Viruses, genes, and ecosystems: Lifestyles and life cycles -- Lysogeny: exercising temperance -- Kill the winner -- Gene brokers -- Selfishness driving adaptive evolution -- Phages and the microbiome -- Unfriendly competition -- Chemical warfare -- 3. Potentiation of bacterial diseases by phages: For a charm of powerful trouble -- Toxic enablers -- Choose your poison -- Treasure islands -- Prophage induction and antibiotic drug resistance -- 4. Viruses and higher organisms: Viruses, cells, organisms, and populations -- "Just a virus" -- Human rhinoviruses -- Uncommon diversity -- Accidents of pathogenesis -- Mutation, diversity, and quasipecies -- 5. The flu: no common cold: Antigenic escape artists -- Human influenza a virus -- Epidemic influenza: dress for the season -- Quasispecies, sequence clusters, and codon bias -- Correlating genetic and antigenic evolution -- Seeding of seasonal epidemics -- Pandemic influenza: the emperor with no clothes -- 6. Alternative virus lifestyles: Latency: 'til death do us part -- All in the family Herpesviridae -- 7. Evolutionary mechanisms of DNA viruses: Gene duplication and gene capture -- Poxvirus evolution -- Poxvirus party tricks -- Small DNA virus evolution -- 8. Viroids and megaviruses: extremes: Viroids: the smallest -- Evolutionary reliquary -- Megaviruses: the biggest -- Big and bigger -- Virophages: fleas upon fleas -- Chimerism -- Megavirus origins: mavericks at heart -- 10. HIV-1: a very modern pandemic: A new disease and a new virus -- Anatomy of HIV-1 -- HIV in the making -- Socioepidemiology of AIDS: a man-made epidemic -- Within-host evolution: a very personal arms race -- Short-sighted evolution -- Adaptive evolution: an evolving relationship -- Outrunning the red queen -- Medicine at the virus-host interface -- Resistance is futile -- 10. Cross-species infections: means and opportunity: A rogue's gallery of emerging viruses -- Adaptive evolution in zoonosis -- Fitness landscape -- A shifting fitness landscape -- The paradox in RNA virus evolution -- RNA viruses and molecular clocks -- Arboviruses: vector-borne viruses -- Evolutionary compromise -- Host restriction -- 11. Future pandemic influenza: enemy at the gates: Real and present danger -- Pandemic threat level -- The pandemic phenotype -- Outbreak -- 12. Ebolavirus: EBOV Makona -- What we were afraid to say about Ebola -- Evolution or adaptive change -- EBOV persistence -- 13. Viral zoonoses and animal reservoirs: The usual suspects -- Filovirus origins -- Bats and viral zoonoses -- A special relationship -- Tolerance and resistance -- 14. Endogenous retroviruses: our viral heritage: Genome invasion by retroviruses -- Endogenization in progress -- Change agents -- Domestication of ERV genes -- Endogenous viral elements -- 15. Viruses as human tools: Myxoma virus: biological control -- Genomics of an attenuated poxvirus -- Orthopoxviruses: past solutions and future problems -- Live-attenuated viruses -- Attenuation by design -- Virus therapeutics -- Doctor's little helpers -- Oncolytic viruses -- 16. Humanity and viruses: The human future and viruses -- Beauty in designZusammenfassung: 1. Obligate parasites of cells: Discovery -- The virosphere and its metagenome -- Complexity and "dark matter" -- Selfish information and the essence of being viral -- The emergence of egotistical replicators -- The viral empire -- 2. Viruses, genes, and ecosystems: Lifestyles and life cycles -- Lysogeny: exercising temperance -- Kill the winner -- Gene brokers -- Selfishness driving adaptive evolution -- Phages and the microbiome -- Unfriendly competition -- Chemical warfare -- 3. Potentiation of bacterial diseases by phages: For a charm of powerful trouble -- Toxic enablers -- Choose your poison -- Treasure islands -- Prophage induction and antibiotic drug resistance -- 4. Viruses and higher organisms: Viruses, cells, organisms, and populations -- "Just a virus" -- Human rhinoviruses -- Uncommon diversity -- Accidents of pathogenesis -- Mutation, diversity, and quasipecies -- 5. The flu: no common cold: Antigenic escape artists -- Human influenza a virus -- Epidemic influenza: dress for the season -- Quasispecies, sequence clusters, and codon bias -- Correlating genetic and antigenic evolution -- Seeding of seasonal epidemics -- Pandemic influenza: the emperor with no clothes -- 6. Alternative virus lifestyles: Latency: 'til death do us part -- All in the family Herpesviridae -- 7. Evolutionary mechanisms of DNA viruses: Gene duplication and gene capture -- Poxvirus evolution -- Poxvirus party tricks -- Small DNA virus evolution -- 8. Viroids and megaviruses: extremes: Viroids: the smallest -- Evolutionary reliquary -- Megaviruses: the biggest -- Big and bigger -- Virophages: fleas upon fleas -- Chimerism -- Megavirus origins: mavericks at heart -- 10. HIV-1: a very modern pandemic: A new disease and a new virus -- Anatomy of HIV-1 -- HIV in the making -- Socioepidemiology of AIDS: a man-made epidemic -- Within-host evolution: a very personal arms race -- Short-sighted evolution -- Adaptive evolution: an evolving relationship -- Outrunning the red queen -- Medicine at the virus-host interface -- Resistance is futile -- 10. Cross-species infections: means and opportunity: A rogue's gallery of emerging viruses -- Adaptive evolution in zoonosis -- Fitness landscape -- A shifting fitness landscape -- The paradox in RNA virus evolution -- RNA viruses and molecular clocks -- Arboviruses: vector-borne viruses -- Evolutionary compromise -- Host restriction -- 11. Future pandemic influenza: enemy at the gates: Real and present danger -- Pandemic threat level -- The pandemic phenotype -- Outbreak -- 12. Ebolavirus: EBOV Makona -- What we were afraid to say about Ebola -- Evolution or adaptive change -- EBOV persistence -- 13. Viral zoonoses and animal reservoirs: The usual suspects -- Filovirus origins -- Bats and viral zoonoses -- A special relationship -- Tolerance and resistance -- 14. Endogenous retroviruses: our viral heritage: Genome invasion by retroviruses -- Endogenization in progress -- Change agents -- Domestication of ERV genes -- Endogenous viral elements -- 15. Viruses as human tools: Myxoma virus: biological control -- Genomics of an attenuated poxvirus -- Orthopoxviruses: past solutions and future problems -- Live-attenuated viruses -- Attenuation by design -- Virus therapeutics -- Doctor's little helpers -- Oncolytic viruses -- 16. Humanity and viruses: The human future and viruses -- Beauty in designPPN: PPN: 893102067Package identifier: Produktsigel: ZDB-4-EBA | ZDB-4-NLEBK

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