Nonclinical drug administration : formulations, routes and regimens for solving drug delivery problems in animal model systems / Shayne C. Gad and Charles B. Spainhour

By: Contributor(s): Resource type: Ressourcentyp: Buch (Online)Book (Online)Language: English Publisher: Boca Raton, FL : CRC Press, 2017Edition: First editionDescription: 1 Online-RessourceSubject(s): Additional physical formats: 9781466502598 | 9781351643610 | 9781351634120 | 1315117347. | 9781315117348. | Erscheint auch als: 9781315117348 Druck-AusgabeLOC classification:
  • RS420
Online resources: Summary: "The concept of the perfect medicine as a molecule that goes with high selectivity to the therapeutic target site, does what it needs to do, and is subsequently cleared from the body is especially relevant now. Much of the current costs and post-market safety concerns arise from the inability to achieve adequate concentrations and selectivity in the due course of actually delivering the active drug. Providing an integrated approach, this book presents ways of achieving the desired adequate and selective delivery using the currently available technology in three tool sets: route, regimen, and formulation."--Provided by publisherSummary: Cover ; Half title ; Title page; Copyright ; Dedication ; Contents; Preface; About the Author; Chapter 1: Introduction; Receptor Theory of Drug Efficacy and Drug Toxicity; References; Chapter 2: Pharmacotherapy, Toxicodynamics, and Regulatory Science -- Divergent Objectives; Introduction; References; Chapter 3: Nonclinical Pharmacokinetics and Toxicokinetics -- A Primer; Introduction; Regulations; Principles; Preliminary Work; Absorption; Absorption from the Pulmonary System; Absorption across the Skin; Parameters Controlling Absorption; Distribution; Protein Binding; Water SolubilitySummary: Chapter 4: Routes of Administration: With Considerations for Species SpecificityBioavailability and Thresholds; Dermal Route; Parenteral Route; Intravenous Route (IV); Bolus versus Infusion; Intramuscular Route (IM); Subcutaneous Route (SC); Intraperitoneal Route (IP); Oral Routes (PO); Mechanisms of Absorption; Factors Affecting Oral Absorption; Techniques of Oral Administration; Buccal and Sublingual; Lesser Routes; Perocular and Intraocular Routes; Rectal Administration; Vaginal Administration; Nasal Administration; Implantation; Route Comparisons and Contrasts; Volume Limitations by RouteSummary: Chapter 4: Routes of Administration: With Considerations for Species SpecificityBioavailability and Thresholds; Dermal Route; Parenteral Route; Intravenous Route (IV); Bolus versus Infusion; Intramuscular Route (IM); Subcutaneous Route (SC); Intraperitoneal Route (IP); Oral Routes (PO); Mechanisms of Absorption; Factors Affecting Oral Absorption; Techniques of Oral Administration; Buccal and Sublingual; Lesser Routes; Perocular and Intraocular Routes; Rectal Administration; Vaginal Administration; Nasal Administration; Implantation; Route Comparisons and Contrasts; Volume Limitations by RouteSummary: "The concept of the perfect medicine as a molecule that goes with high selectivity to the therapeutic target site, does what it needs to do, and is subsequently cleared from the body is especially relevant now. Much of the current costs and post-market safety concerns arise from the inability to achieve adequate concentrations and selectivity in the due course of actually delivering the active drug. Providing an integrated approach, this book presents ways of achieving the desired adequate and selective delivery using the currently available technology in three tool sets: route, regimen, and formulation."--Provided by publisherPPN: PPN: 1003039790Package identifier: Produktsigel: ZDB-4-NLEBK
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