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The science of stem cells / Jonathan M. W. Slack

By: Resource type: Ressourcentyp: Buch (Online)Book (Online)Language: English Publisher: Hoboken, NJ : Wiley, 2017Description: 1 Online-RessourceISBN:
  • 9781119235255
  • 9781119235231
Subject(s): Additional physical formats: 9781119235156. | Erscheint auch als: The science of stem cells. Druck-Ausgabe Hoboken, NJ : Wiley Blackwell, 2018. xiii, 248 SeitenDDC classification:
  • 616.02/774
RVK: RVK: WE 2600 | WX 6640 | WX 6600 | WX 6000LOC classification:
  • QH588.S83
Online resources: Summary: ""In Situ Hybridization""""Other Methods""; ""RNAseq""; ""Laser Capture Microdissection""; ""Flow Cytometry""; ""Dividing Cells""; ""The Cell Cycle""; ""Studying Cell Turnover""; ""Reporters for the Cell Cycle""; ""Identification of Very Slow Cell Turnover""; ""Classification of Cell Types by Proliferative Behavior""; ""Cell Death""; ""Further Reading""; ""Chapter 3 Genetic Modification and the Labeling of Cell Lineages""; ""Introducing Genes to Cells""; ""Transfection and Electroporation""; ""Gene Delivery Viruses""; ""Controlling Gene Expression""; ""Tet System""; ""Cre SystemSummary: ""Inhibiting Gene Activity""""CRISPRâ#x80;#x90;Cas9""; ""Transgenic Mice""; ""Animal Procedures""; ""Modification of Embryonic Stem Cells""; ""Types of Transgenic Mice""; ""Cell Lineage""; ""Cell Lineage, Fate Maps, Clonal Analysis""; ""Use of CreER for Lineage Analysis""; ""Retroviral Barcoding""; ""Clonal Analysis in Humans""; ""Further Reading""; ""Chapter 4 Tissue Culture, Tissue Engineering and Grafting""; ""Simple Tissue Culture""; ""Media""; ""Contamination""; ""Growth in Culture""; ""Cryopreservation and Banking""; ""GMP Cultivation""; ""Complex Tissue CultureSummary: ""Induced Differentiation""""Three Dimensional Cell Culture""; ""Artificial Organs and Organoids""; ""Grafting""; ""The Immune System""; ""T Cells""; ""The Major Histocompatibility Complex""; ""T and B Cell Responses""; ""Reactions to a Graft""; ""Immunosuppressive Drugs""; ""Animal Experiments Involving Grafting""; ""Further Reading""; ""Chapter 5 Early Mouse and Human Development""; ""Gametogenesis""; ""Germ Cells""; ""Mitosis and Meiosis""; ""Primordial Germ Cells (PGCs)""; ""Spermatogenesis""; ""Oogenesis""; ""Fertilization""; ""Early Development""; ""Preimplantation PhaseSummary: "Introduces all of the essential cell biology and developmental biology background for the study of stem cells. This book gives you all the important information you need to become a stem cell scientist. It covers the characterization of cells, genetic techniques for modifying cells and organisms, tissue culture technology, transplantation immunology, properties of pluripotent and tissue specific stem cells and, in particular, the relevant aspects of mammalian developmental biology. It dispels many misconceptions about stem cells, especially that they can be miracle cells that can cure all ills. The book puts emphasis on stem cell behavior in its biological context and on how to study it. Throughout, the approach is simple, direct, and logical, and evidence is given to support conclusions. Stem cell biology has huge potential for advancing therapies for many distressing and recalcitrant diseases, and its potential will be realized most quickly when as many people as possible have a good grounding in the science of stem cells. Content focused on the basic science underpinning stem cell biology Covers techniques of studying cell properties and cell lineage in vivo and in vitro Explains the basics of embryonic development and cell differentiation, as well as the essential cell biology processes of signaling, gene expression, and cell division Includes instructor resources such as further reading and figures for downloading Offers an online supplement summarizing current clinical applications of stem cells Written by a prominent leader in the field, The Science of Stem Cells is an ideal course book for advanced undergraduates or graduate students studying stem cell biology, regenerative medicine, tissue engineering, and other topics of science and biology."--PPN: PPN: 100753933XPackage identifier: Produktsigel: ZDB-4-NLEBK
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