Voltage-gated Sodium Channels: Structure, Function and Channelopathies / edited by Mohamed Chahine

Mitwirkende(r):

Chahine, Mohamed [HerausgeberIn]

Resource type: Ressourcentyp: Buch (Online)Buch (Online)Sprache: Englisch Reihen: Handbook of Experimental Pharmacology ; 246 | Springer eBook Collection | SpringerLink BücherVerlag: Cham : Springer International Publishing, 2018Beschreibung: Online-Ressource (X, 450 p. 80 illus., 55 illus. in color, online resource)ISBN:

9783319902845

Schlagwörter:

Andere physische Formen: 9783319902838 | Erscheint auch als: Handbook of experimental pharmacology ; volume 246: Voltage-gated sodium channels. Cham, Switzerland : Springer, 2018. X, 450 Seiten | Printed edition: 9783319902838 DDC-Klassifikation:

RVK: RVK: XI 1701LOC-Klassifikation:

RM1-950

NLM-Klassifikation:

QU 55.7

DOI: DOI: 10.1007/978-3-319-90284-5Online-Ressourcen:

Zusammenfassung: This book provides a timely state-of-the-art overview of voltage-gated sodium channels, their structure-function, their pharmacology and related diseases. Among the topics discussed are the structural basis of Na+ channel function, methodological advances in the study of Na+ channels, their pathophysiology and drugs and toxins interactions with these channels and their associated channelopathiesZusammenfassung: Preface -- Part I -- Evolution of voltage-gated sodium channels -- 1. Evolutionary History of Voltage-Gated Sodium Channels -- 2. Mining Protein Evolution for Insights into Mechanisms of Voltage-Dependent Sodium Channel Auxiliary Subunits. - Part II. The structural basis of sodium channel function -- 3. Structural and Functional Analysis of Sodium Channels Viewed from an Evolutionary Perspective -- 4. The Cardiac Sodium Channel and Its Protein Partners -- 5. : Posttranslational Modification of Sodium Channels -- 6. Sodium Channel Trafficking -- 7. pH Modulation of Voltage-Gated Sodium Channels -- 8. Regulation of Cardiac Voltage-Gated Sodium Channel by Kinases: Roles of Protein Kinases A and C -- Part III. Drugs and toxins interactions with sodium channels -- 9. Toxins That Affect Voltage-Gated Sodium Channels -- 10. Mechanisms of Drug Binding to Voltage-Gated Sodium Channels -- 11. Effects of Benzothiazolamines on Voltage-Gated Sodium Channels -- 12. Structural Models of Ligand-Bound Sodium Channels -- 13. Selective Ligands and Drug Discovery Targeting the Voltage-Gated Sodium Channel Nav1.7 -- Part IV. Pathophysiology of sodium channels -- 14. Sodium Channelopathies of Skeletal Muscle -- 15. Cardiac Arrhythmias Related to Sodium Channel Dysfunction -- 16. Translational Model Systems for Complex Sodium Channel Pathophysiology in Pain -- 17. Gating Pore Currents in Sodium Channels -- 18. Calculating the Consequences of Left-Shifted Nav Channel Activity in Sick Excitable Cells -- 19. Voltage-Gated Sodium Channel b Subunits and Their Related DiseasesPPN: PPN: 1026854938Package identifier: Produktsigel: ZDB-2-SBL | ZDB-2-SEB | ZDB-2-SXB

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