Delta Opioid Receptor Pharmacology and Therapeutic Applications / edited by Emily M. Jutkiewicz

Mitwirkende(r):

Jutkiewicz, Emily M [HerausgeberIn]

Resource type: Ressourcentyp: Buch (Online)Buch (Online)Sprache: Englisch Reihen: Handbook of Experimental Pharmacology ; 247 | Springer eBook Collection | SpringerLink BücherVerlag: Cham : Springer International Publishing, 2018Beschreibung: Online-Ressource (VIII, 345 p, online resource)ISBN:

9783319951331

Schlagwörter:

Andere physische Formen: 9783319951317 | 9783319951324 | Erscheint auch als: 978-3-319-95131-7 Druck-Ausgabe | Printed edition: 9783319951317 | Printed edition: 9783319951324 DDC-Klassifikation:

LOC-Klassifikation:

RM1-950

NLM-Klassifikation:

QV 36

DOI: DOI: 10.1007/978-3-319-95133-1Online-Ressourcen:

Zusammenfassung: This volume describes our current understanding of the biological role of the delta-opioid receptor (DOR) system, focusing on its unique mechanisms of receptor trafficking and signaling in disease states. Part 1 covers the endogenous ligands that regulate the DOR system as well as novel compounds and therapies used to modulate the DOR system. Part 2 describes new insights into the localization and trafficking of the DOR and how ligand-directed signaling alters the fate of the receptor. Part 3 concentrates on the potential role of the DOR system in disease states, such as pain, mood, addiction, and Parkinson’s disease. Throughout the book, the DOR system as a target for drug development will be discussedZusammenfassung: Part 1. DOPR Ligands -- 1. Delta Opioid Receptor (DOR) Ligands and Pharmacology: Development of Indolo- and Quinolinomorphinan Derivatives Based on the Message-Address Concept -- 2. Multifunctional Opioid Ligands -- 3. Contribution of Delta-Opioid Receptors to Pathophysiological Events Explored by Endogenous Enkephalins -- Part 2. DOPR Signaling -- 4. Ligand-Directed Signaling at the Delta Opioid Receptor -- 5. Delta Opioid Receptor Expression and Function in Primary Afferent Somatosensory Neurons -- 6. Evidence and Function Relevance of Native DOR-MOR Heteromers -- Part 3. DOPR and Disease -- 8. The Delta Opioid Receptor in Pain Control -- 9. Delta Opioid Receptors and Modulation of Mood and Emotion -- 10. Delta Opioid Pharmacology in Relation to Alcohol Behaviors -- 11. Delta Opioid Receptors: Learning and Motivation -- 12. Delta Opioid Pharmacology in Parkinson’s Disease -- 13. Delta Opioid Receptor and Peptide: A Dynamic Therapy for Stroke and Other Neurological Disorders -- 14. Delta Opioid Receptors and Cardioprotection -- 15. The Roles of Opioid Receptors in Cutaneous Wound HealingPPN: PPN: 1031840311Package identifier: Produktsigel: ZDB-2-SBL | ZDB-2-SEB | ZDB-2-SXB

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