Custom cover image
Custom cover image

Integrative Structural Biology with Hybrid Methods / edited by Haruki Nakamura, Gerard Kleywegt, Stephen K. Burley, John L. Markley

Contributor(s): Resource type: Ressourcentyp: Buch (Online)Book (Online)Language: English Series: Advances in Experimental Medicine and Biology ; 1105 | SpringerLink BücherPublisher: Singapore : Springer Singapore, 2018Description: Online-Ressource (VI, 272 p. 61 illus., 44 illus. in color, online resource)ISBN:
  • 9789811322006
Subject(s): Additional physical formats: 9789811321993 | 9789811322013 | Printed edition: 9789811321993 | Printed edition: 9789811322013 DDC classification:
  • 572.633
LOC classification:
  • QD431-431.7
NLM classification:
  • QD 461
DOI: DOI: 10.1007/978-981-13-2200-6Online resources: Summary: This book presents a new emerging concept of "Integrative Structural Biology". It covers current trends of the molecular and cellular structural biology, providing new methods to observe, validate, and keep the structural models of the large cellular machines with recent scientific results. Structures of very large macromolecular machines in cells are being determined by combining observations from complementary experimental methods. Thus, this volume presents the each methods such as X-ray crystallography, NMR spectroscopy, 3DEM, small-angle scattering (SAS), FRET, crosslinking, and enables the readers to understand the hybrid methods. This book discusses how those integrative models should be represented, validated and archived. A unique highlight of this book is discussion of the data validation and archive, which are big problems in this filed along with the progress of this field. The researchers in biology will be interested in this book as a guide book for learning the current structure biology, but also those in structure biology may use this book as a comprehensive reference to cover broad topicsSummary: Part-1.Introduction and historical background -- Chapter 1.Overall introduction and rationale, with View from computational biology -- Chapter 2.Integrative/Hybrid Methods Structural Biology: Role of Macromolecular Crystallography -- Chapter 3.View from nuclear magnetic resonance spectroscopy -- Part- 2.New experimental tools enabling hybrid methods -- Chapter 4.Complementary use of electron cryomicroscopy and X-ray crystallography: Structural studies of actin and actomyosin filaments -- Chapter 5.Current solution NMR techniques for structure-function studies of proteins and RNA molecules -- Chapter 6.The PA tag: a versatile peptide tagging system in the era of integrative structural biology -- Chapter 7.Small angle scattering and structural biology: Data quality and model validation -- Chapter 8.Structural investigation of proteins and protein complexes by chemical cross-linking/mass spectrometry -- Chapter 9.Prediction of structures and interactions from genome information -- Chapter 10.A hybrid approach for protein structure determination combining sparse NMR with evolutionary coupling sequence data (EC-NMR) -- Chapter 11.Harnessing the combined power of SAXS and NMR -- Chapter 12.2D Hybrid analysis -- Part-3.New computational tools enabling hybrid methods -- Chapter 13.Hybrid methods for macromolecular modeling by molecular mechanics simulations with experimental data -- Chapter 14.Rigid-body fitting of atomic models on 3D density maps of electron microscopy -- Chapter 15.Hybrid methods for modeling protein structures using molecular dynamics simulations and small-angle X-ray scattering data -- Part-4.Data validation and archives for hybrid methods -- Chapter 16.Archiving pf integrative/hybrid modelsPPN: PPN: 104836271XPackage identifier: Produktsigel: ZDB-2-SBL | ZDB-2-SEB | ZDB-2-SXB
No physical items for this record

Reproduktion. (Springer eBook Collection. Biomedical and Life Sciences)

KIT – The Research University in the Helmholtz Association                         Home | Impressum | Datenschutz | Barrierefreiheit | KIT