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Mechanisms of Drug Resistance in Cancer Therapy / edited by Mario Mandalà, Emanuela Romano

Contributor(s): Resource type: Ressourcentyp: Buch (Online)Book (Online)Language: English Series: Handbook of Experimental Pharmacology ; 249 | Springer eBook Collection | SpringerLink BücherPublisher: Cham : Springer International Publishing, 2018Description: Online-Ressource (VIII, 297 p. 32 illus., 31 illus. in color, online resource)ISBN:
  • 9783030105075
Subject(s): Additional physical formats: 9783030105068 | 9783030105082 | Erscheint auch als: Handbook of experimental pharmacology ; volume 249: Mechanisms of drug resistance in cancer therapy. Druck-Ausgabe. Cham, Switzerland : Springer, 2018. viii, 297 Seiten | Printed edition: 9783030105068 | Printed edition: 9783030105082 DDC classification:
  • 615
RVK: RVK: VT 5200LOC classification:
  • RM1-950
NLM classification:
  • QZ 267
DOI: DOI: 10.1007/978-3-030-10507-5Online resources: Summary: A major objective of this book is to reveal unprecedented opportunities to understand and overcome drug resistance through the clinical assessment of rational therapeutic drug combinations and the use of predictive and prognostic biomarkers to enable patient stratification and tailor treatments. It offers to the readers an updated overview on the possible reasons of failure of new and promising therapeutic opportunitiesSummary: 1. Molecular and Pharmacological Mechanisms of Drug Resistance: An Evolving Paradigm -- 2. Major Physiological Signaling Pathways in the Regulation of Cell Proliferation and Survival -- 3. Immune-Mediated and Hypoxia-Regulated Programs: Accomplices in Resistance to Anti-angiogenic Therapies -- 4. Mechanisms of Resistance to Target Therapies in Non-small Cell Lung Cancer -- 5. Mechanisms of Drug Resistance in Melanoma -- 6. Mechanisms of Resistance to Immune Checkpoint Antibodies -- 7. Immunotolerance as a Mechanism of Resistance to Targeted Therapies in Melanoma -- 8. Plasticity of Resistance and Sensitivity to Anti-Epidermal Growth Factor Receptor Inhibitors in Metastatic Colorectal Cancer -- 9. Targeting DNA repair -- 10. Resistance to Hormonal Therapy in Prostate Cancer -- 11. Mechanism of Resistance in Gastrointestinal Stromal Tumors -- 12. Mechanisms of Resistance to Targeted Therapies in Chronic Lymphocytic Leukemia -- 13. Mechanisms of Resistance to Targeted Therapies in Chronic Myeloid Leukemia -- 14. Mechanisms of Resistance in Multiple Myeloma -- 15. Cancer Evolution as the New Frontier of PrecisionPPN: PPN: 1048363198Package identifier: Produktsigel: ZDB-2-SBL | ZDB-2-SEB | ZDB-2-SXB
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Reproduktion. (Springer eBook Collection. Biomedical and Life Sciences)

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